What are the differential diagnoses of shoulder pain?

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Last updated: May 8, 2025View editorial policy

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Differential Diagnosis of Shoulder Pain

The differential diagnosis of shoulder pain can be organized into the following categories:

  • Single Most Likely Diagnosis
    • Rotator cuff tendinitis: This is the most common cause of shoulder pain, often resulting from repetitive strain or acute injury to the rotator cuff muscles and tendons.
  • Other Likely Diagnoses
    • Adhesive capsulitis (frozen shoulder): Characterized by stiffness and limited range of motion in the shoulder joint, often following trauma or inflammation.
    • Bursitis: Inflammation of the bursae, fluid-filled sacs that cushion the joints, can cause pain and swelling in the shoulder.
    • Osteoarthritis: Wear and tear on the joint cartilage can lead to pain, stiffness, and limited mobility in the shoulder.
    • Labral tears: Tears in the labrum, a cartilage ring surrounding the socket of the shoulder joint, can cause pain and instability.
  • Do Not Miss Diagnoses
    • Pulmonary embolism: Referred pain from a pulmonary embolism can manifest as shoulder pain, making it crucial to consider this diagnosis, especially in patients with risk factors.
    • Myocardial infarction: Referred pain from a heart attack can also present as shoulder pain, emphasizing the need for a thorough cardiovascular evaluation.
    • Spinal cord injury or cervical radiculopathy: Nerve compression or injury in the cervical spine can cause radiating pain to the shoulder, necessitating a careful neurological examination.
    • Infection (septic arthritis or osteomyelitis): Bacterial or fungal infections in the shoulder joint or bone can lead to severe pain, swelling, and potential long-term damage if not promptly treated.
  • Rare Diagnoses
    • Rheumatoid arthritis: Although less common in the shoulder, rheumatoid arthritis can cause inflammation, pain, and stiffness in the joint.
    • Polymyalgia rheumatica: This inflammatory condition can cause widespread muscle pain, including the shoulder region.
    • Pancoast tumor: A rare type of lung cancer that can cause shoulder pain due to local invasion of the tumor.
    • Brachial plexus injury: Trauma to the brachial plexus nerves can result in shoulder pain, numbness, and weakness.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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