From the Guidelines

Nigella sativa, also known as black seed, is not recommended as a treatment for HIV due to lack of strong evidence supporting its effectiveness.

The standard treatment for HIV is antiretroviral therapy (ART), which typically involves a combination of medications such as tenofovir, emtricitabine, and efavirenz 1.
These medications have been proven to be effective in suppressing the virus and preventing disease progression.
Using Nigella sativa as a replacement for ART or as a complementary therapy without consulting a healthcare provider is not advised, as it may lead to delayed or inadequate treatment, potentially resulting in poor health outcomes.
If you are considering using Nigella sativa for HIV, consult with a healthcare provider to discuss the potential risks and benefits and to determine the best course of treatment.

The provided evidence does not support the use of Nigella sativa as a treatment for HIV, and the focus should be on established treatments like ART.
ART regimens, such as those including tenofovir, emtricitabine, and efavirenz, are well-documented and recommended by health authorities 1.
The management of HIV infection, especially in cases of coinfection with other viruses like HBV, requires careful consideration of the treatment regimen to avoid drug resistance and ensure maximal suppression of viral replication 1.

From the Research

The seed of Nigella sativa has been used to treat various ailments, including infectious diseases due to viral infections 2.
A case presentation reported the complete recovery and sero-reversion of an adult HIV patient after treatment with Nigella sativa concoction for six months 3.
The patient's CD4 count increased to 650 cells/mm3 with undetectable viral load after treatment, and several repeats of the HIV tests remained sero-negative, aviraemia, and normal CD4 count since 24 months without herbal therapy 3.
Nigella sativa has been shown to have anti-inflammatory, anti-microbial, anti-cancer, anti-oxidant, anti-diabetic, and anti-hypertensive activities, which may be beneficial in treating HIV-related complications 4.
The phytochemical compounds in Nigella sativa, such as thymoquinone, may confer an antioxidant effect and potent anti-inflammatory effect, which could be useful in reducing the therapeutic dose of other drugs and overcoming obstacles such as drug resistance 5.

Nigella sativa may have a synergistic effect with other drugs, such as chemotherapeutic agents or antibiotics, which may lead to a reduction in the therapeutic dose and improved effect 5.
The seeds of Nigella sativa may be used as a valuable plant for production of new drugs for treatment of many diseases, including HIV 4.
Further investigations are needed to understand the therapeutic profile and the most effective mode of administration of Nigella sativa, as well as its toxicological profile 5.

Despite the promising efficacy of Nigella sativa against HIV/AIDS, limited studies have been conducted, and more research is needed to substantiate its full therapeutic efficacy 2.
Human reports on the efficacy of Nigella sativa as an antidote or protective agent in human intoxication are rare, and further studies are required to determine its efficacy in humans 6.