What is the differential diagnosis (DDX) for acute diverticulitis?

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Differential Diagnosis for Acute Diverticulitis

Single Most Likely Diagnosis

  • Acute diverticulitis: This is the most likely diagnosis given the presentation, as diverticulitis is a common condition characterized by inflammation of a diverticulum in the wall of the colon, often presenting with acute abdominal pain, tenderness, and changes in bowel habits.

Other Likely Diagnoses

  • Irritable bowel syndrome (IBS): Although IBS is a chronic condition, its symptoms can sometimes mimic those of acute diverticulitis, including abdominal pain and changes in bowel habits.
  • Inflammatory bowel disease (IBD): Conditions like Crohn's disease and ulcerative colitis can present with similar symptoms to diverticulitis, including abdominal pain, diarrhea, and weight loss.
  • Gastroenteritis: Infection of the stomach and intestines can cause acute abdominal pain, diarrhea, and vomiting, which might be confused with diverticulitis.
  • Appendicitis: Although the pain location differs, appendicitis can sometimes present with similar systemic symptoms like fever and abdominal tenderness.

Do Not Miss Diagnoses

  • Perforated viscus: A hole in the wall of the intestine can lead to peritonitis, which is life-threatening and requires immediate surgical intervention. The symptoms can overlap with diverticulitis, especially if there's associated peritonitis.
  • Ectopic pregnancy: In women of childbearing age, an ectopic pregnancy can present with acute abdominal pain and might be mistaken for diverticulitis. It's a medical emergency that requires prompt diagnosis and treatment.
  • Mesenteric ischemia: Reduced blood flow to the intestines can cause severe abdominal pain and might be confused with diverticulitis. It's a serious condition that can lead to bowel infarction if not treated promptly.
  • Ovarian torsion: In women, ovarian torsion can cause severe, acute abdominal pain and might be mistaken for diverticulitis. It's an emergency that requires immediate surgical intervention.

Rare Diagnoses

  • Epiploic appendagitis: Inflammation of the epiploic appendages (small, fatty structures attached to the colon) can cause acute abdominal pain and might be confused with diverticulitis.
  • Colonic volvulus: Twisting of a portion of the colon can cause acute abdominal pain, obstruction, and might be mistaken for diverticulitis.
  • Intussusception: Telescoping of one segment of intestine into another can cause acute abdominal pain, obstruction, and might be confused with diverticulitis, especially in adults.
  • Solitary rectal ulcer syndrome: Although more chronic, this condition can sometimes present acutely and might be mistaken for diverticulitis due to overlapping symptoms like rectal pain and bleeding.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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