From the Guidelines
Gvoke should not be refrigerated before opening, and it is recommended to store it at room temperature between 68°F to 77°F (20°C to 25°C) in its original packaging to protect it from light. This is based on the most recent evidence from 1, which emphasizes the importance of storing glucagon products according to specific product instructions to ensure safe and effective use. The study highlights that newer formulations of glucagon, such as Gvoke, have improved physical and chemical stability, but it is still crucial to follow proper storage guidelines.
Key Storage Considerations
- Store Gvoke at room temperature between 68°F to 77°F (20°C to 25°C)
- Keep it in its original packaging to protect it from light
- Avoid storing Gvoke in extreme temperatures above 86°F (30°C) or freezing conditions
- Always check the expiration date before use
- Inspect the solution to ensure it's clear and colorless to pale yellow before administration It is essential to note that refrigeration can potentially affect the stability and efficacy of the medication, which is designed for emergency treatment of severe hypoglycemia 1. The pre-filled syringe (Gvoke PFS) and auto-injector (Gvoke HypoPen) formulations are specifically formulated to remain stable at room temperature, making them convenient for carrying with you.
From the FDA Drug Label
Store Glucagon at room temperature between 68°F to 77°F (20°C to 25°C) for up to 24 months (2 years). Do not freeze Glucagon The package containing Glucagon for Injection vials may be stored up to 24 months at 20° to 25° C (68° to 77° F) [see USP Controlled Room Temperature] prior to reconstitution. Do not freeze.
No, you should not keep Gvoke refrigerated, it should be stored at room temperature between 68°F to 77°F (20°C to 25°C) and should not be frozen 2 2.
From the Research
Storage of Gvoke
- Gvoke is a type of glucagon used to treat severe hypoglycemia, but the provided studies do not specifically mention the storage requirements for Gvoke.
- However, it can be inferred that glucagon formulations, including Gvoke, may have specific storage instructions to maintain their efficacy.
- According to the study 3, new ready-to-use glucagons like Gvoke have been developed, but the storage requirements for these formulations are not explicitly stated in the provided texts.
General Storage of Glucagon
- The studies provided do not offer direct information on the storage of glucagon or Gvoke.
- It is essential to consult the packaging or manufacturer's instructions for specific storage guidelines, as the storage conditions may vary depending on the formulation and type of glucagon.
- The studies 4, 5, 6, and 7 discuss the importance of glucagon in treating severe hypoglycemia but do not provide information on storage requirements.
Conclusion on Storage Information
- There is no direct information available in the provided studies regarding the storage of Gvoke or whether it needs to be refrigerated.
- For accurate storage instructions, it is recommended to consult the product label or contact the manufacturer, as the storage conditions may be specific to the product and formulation.