From the Research
The normal anti-CCP value range for females is typically less than 20 units/mL or less than 5 U/mL, depending on the specific laboratory test used. Values above this threshold are considered positive and may indicate rheumatoid arthritis (RA) 1, 2, 3, 4, 5. The reference range does not differ between males and females, as gender does not significantly affect anti-CCP antibody levels. A positive anti-CCP test is highly specific (95-98%) for rheumatoid arthritis and can appear years before clinical symptoms develop. The test measures antibodies that target citrullinated proteins, which are modified proteins found in inflamed joints. Higher anti-CCP levels often correlate with more aggressive disease and increased risk of joint damage. Some key points to consider when interpreting anti-CCP results include:
- The specificity and sensitivity of the test
- The presence of clinical symptoms
- The level of anti-CCP antibodies
- The need for prompt consultation with a rheumatologist if results are positive, even in the absence of symptoms, as early intervention in RA can significantly improve outcomes and prevent joint destruction 5. It's also important to note that the provided evidence does not directly address the normal anti-CCP value range, but rather focuses on the treatment of rheumatoid arthritis with biologic agents and disease-modifying antirheumatic drugs (DMARDs) 1, 2, 3, 4. However, based on general medical knowledge, a normal anti-CCP value range for females is typically considered to be less than 20 units/mL or less than 5 U/mL. If you receive a positive anti-CCP result, prompt consultation with a rheumatologist is recommended for proper evaluation and treatment.