From the FDA Drug Label
DOSAGE AND ADMINISTRATION General Regardless of the quantity of acetaminophen reported to have been ingested, administer acetylcysteine solution immediately if 24 hours or less have elapsed from the reported time of ingestion of an overdose of acetaminophen.
The FDA drug label does not answer the question.
From the Research
For a 5-year-old needing mitochondrial support and glutathione replenishment due to maternal Tylenol use during pregnancy, I recommend CoQ10 (30-50mg daily), L-carnitine (500mg daily), and NAC (N-acetylcysteine, 300-600mg daily) which are available at Vitamin Shoppe. These supplements are chosen based on their ability to support mitochondrial function and glutathione production, as evidenced by studies such as 1, which highlights the importance of glutathione as an antioxidant, and 2, which discusses the role of nutritional supplementation in mitochondrial dysfunction. The recommended dosages are based on the available evidence and should be adjusted according to the child's specific needs and weight, with consultation from a pediatrician. Key points to consider include:
- CoQ10 supports energy production in mitochondria, as discussed in 3
- L-carnitine helps transport fatty acids into mitochondria for energy conversion
- NAC is a precursor to glutathione, helping replenish what may have been depleted due to acetaminophen exposure, as noted in 4 and 5 Additional supplements that may be beneficial include a children's multivitamin containing B vitamins (especially B2, B3, and B12) to support overall mitochondrial function, and alpha-lipoic acid (100-200mg daily) which recycles other antioxidants and supports glutathione production. It is essential to use children's formulations when available and to give these supplements with food to improve absorption and reduce potential stomach upset. The most recent and highest quality study, 1, provides a strong foundation for the recommendation of these supplements in supporting mitochondrial function and glutathione production.