From the Research
I strongly advise against taking Trombex (clopidogrel) with bevacizumab without medical supervision due to potential increased bleeding risks. Both medications affect blood clotting through different mechanisms - clopidogrel prevents platelets from sticking together while bevacizumab, as an anti-angiogenic cancer treatment, can impair blood vessel formation and healing. This combination may significantly increase your risk of bleeding complications, including serious or potentially life-threatening bleeding events. Some key points to consider when taking these medications together include:
- The risk of bleeding associated with bevacizumab has been reported in several studies, with varying degrees of severity 1, 2, 3.
- A more recent study found that patients with metastatic colorectal cancer treated with bevacizumab and apixaban had a relatively low risk of bleeding that warranted treatment discontinuation 4.
- Another study suggested that the efficacy and safety of anticoagulant therapy in patients with cancer-associated thrombosis receiving bevacizumab is not modified regardless of whether bevacizumab is continued or discontinued 5. If you're currently prescribed both medications, this combination may sometimes be necessary depending on your specific medical conditions, but requires careful monitoring by your healthcare provider. The dosing, timing, and safety of this combination should be determined by your doctor based on your individual medical history, cancer type, cardiovascular risk factors, and overall bleeding risk. Never adjust or combine these medications on your own, and report any unusual bleeding or bruising to your doctor immediately. It's essential to weigh the benefits and risks of this combination and discuss them thoroughly with your healthcare provider to ensure the best possible outcome.