From the Guidelines
To find a cohort report of HIV-infected children, I strongly recommend searching specialized medical databases like PubMed, Cochrane Library, or Google Scholar, using specific search terms such as "HIV pediatric cohort" or "children HIV longitudinal study", and narrowing the search by parameters like age ranges or geographic locations, as this approach is supported by the most recent and highest quality study 1. When searching for cohort reports, it's essential to consider the most recent studies, such as the 2021 study published in Advances in Nutrition 1, which highlights the importance of nutrition in HIV-infected infants and children.
- Key search terms to use include "HIV pediatric cohort", "children HIV longitudinal study", or "HIV-infected children follow-up".
- Narrow the search by adding parameters like age ranges (e.g., "0-18 years"), time periods, geographic locations, or specific outcomes of interest such as "treatment response", "growth outcomes", or "neurodevelopmental effects".
- Major HIV research networks like IMPAACT, PENPACT, or CHIPS have published significant cohort studies on HIV-infected children, as mentioned in the 2014 guidelines for the management of persons infected with HIV 1.
- Consider contacting major HIV treatment centers, university research departments, or organizations like WHO or UNAIDS for access to unpublished data or ongoing studies, as suggested by the 1998 guidelines for the use of antiretroviral agents in pediatric HIV infection 1. When evaluating cohort reports, pay attention to sample size, follow-up duration, treatment protocols (including specific antiretroviral medications like lopinavir/ritonavir, dolutegravir, or abacavir), and outcome measures to ensure the data meets your specific research needs, as emphasized by the 2021 study 1.
From the Research
Cohort Report of HIV Infected Children
There are no research papers to assist in answering this question as the provided studies do not focus on HIV infected children.
Available Studies
- The studies provided focus on the treatment of HIV-infected adults, including the comparison of different antiretroviral regimens 2, 3, 4, 5.
- These studies discuss the efficacy and safety of various treatment combinations, such as abacavir-lamivudine and tenofovir-emtricitabine, in adult patients with HIV-1 infection.
- The studies do not provide information on the treatment or outcomes of HIV-infected children.
Key Findings
- A study published in 2005 compared the efficacy of abacavir and lamivudine administered twice daily with a fixed-dose combination tablet once daily in HIV-infected patients 2.
- A 2018 study evaluated the effectiveness of simplifying antiretroviral therapy to a dual regimen containing lamivudine and darunavir/ritonavir or atazanavir/ritonavir in HIV-infected patients 3.
- Another study published in 2017 compared the virologic effectiveness of abacavir/lamivudine with darunavir/ritonavir versus other protease inhibitors in treatment-experienced HIV-infected patients 4.
- A 2009 study compared the efficacy and safety of abacavir-lamivudine versus tenofovir-emtricitabine for initial HIV-1 therapy 5.