From the Guidelines
There is no strong evidence that CoQ10 supplements directly cause increased urination in most people. CoQ10 is not known to have diuretic properties that would typically lead to more frequent urination. However, some individuals might experience mild side effects when taking CoQ10, which could potentially include changes in urination patterns. The typical dosage of CoQ10 ranges from 100-200 mg daily, and at these standard doses, increased urination is not commonly reported 1. If you notice significant changes in your urination frequency after starting CoQ10, it's worth considering other factors such as increased fluid intake, other medications you might be taking simultaneously, or underlying health conditions. CoQ10 is generally well-tolerated, with the most common side effects being digestive issues rather than urinary changes. Some key points to consider:
- CoQ10 supplementation may be beneficial for reducing blood pressure in patients with cardiometabolic disorders 1.
- The optimal intake of CoQ10 supplementation for daily recommendation is unclear, but 100-200 mg/d is suggested 1.
- CoQ10 supplementation has antioxidant and anti-inflammatory properties, which may contribute to its beneficial effects on blood pressure 1. If you're concerned about increased urination while taking CoQ10, it would be advisable to consult with your healthcare provider to rule out other potential causes.
From the Research
CoQ10 and Urination Frequency
- The available studies do not directly address the question of whether taking CoQ10 can make you pee more 2, 3, 4, 5, 6.
- However, some studies suggest that CoQ10 may have a therapeutic role in detrusor overactivity and bladder dysfunction, which could potentially affect urination frequency 2, 4.
- One study found that CoQ10 administration prolonged micturition frequency and increased bladder capacity in a rat model of chronic bladder ischemia 4.
- Another study investigated the effects of CoQ10 supplementation on lower urinary tract symptoms in men with benign prostatic hyperplasia, but did not report any significant changes in urination frequency 6.
Potential Mechanisms
- CoQ10 may exert its effects on the bladder through anti-inflammatory, anti-oxidant, and channel inhibiting mechanisms 2.
- CoQ10 may also act as an antioxidant to protect bladder function in models of chronic bladder ischemia 4.
- However, the exact mechanisms by which CoQ10 may affect urination frequency are not fully understood and require further study.