Are magnesium, riboflavin (B2), and coenzyme Q10 safe during lactation?

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Last updated: March 20, 2025View editorial policy

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From the Guidelines

Magnesium, vitamin B2 (riboflavin), and coenzyme Q10 are generally considered safe during breastfeeding when taken in appropriate doses. Magnesium is an essential mineral that supports muscle and nerve function, and moderate supplementation (typically 310-360 mg daily for breastfeeding women) is considered safe 1. Vitamin B2 is a water-soluble vitamin important for energy production, and the recommended daily allowance for lactating women is 1.6 mg, as suggested by the WHO 1. Coenzyme Q10 is naturally produced in the body and appears to have minimal transfer into breast milk, with typical supplemental doses ranging from 100-200 mg daily, as indicated by a recent systematic review and meta-analysis 1. These supplements can help address nutritional needs during lactation, as breastfeeding increases demands for certain nutrients. However, it's essential to use only standard recommended doses, as excessive amounts could potentially affect breast milk composition. Before starting any supplements while breastfeeding, consult with your healthcare provider to ensure they're appropriate for your specific situation and won't interact with any medications you may be taking. Key considerations for lactating women include maintaining a balanced diet, staying hydrated, and being mindful of the potential for nutrient deficiencies, particularly in vegan or vegetarian diets 1. The ESPEN micronutrient guideline also provides valuable insights into the role of coenzyme Q10 in mitochondrial bioenergetics and its antioxidant properties, highlighting its importance for overall health 1. Ultimately, the decision to take supplements during breastfeeding should be made in consultation with a healthcare provider, taking into account individual nutritional needs and health status.

From the Research

Safety of Magnesium, Riboflavin (B2), and Coenzyme Q10 During Lactation

  • There are no direct studies on the safety of magnesium, riboflavin (B2), and coenzyme Q10 during lactation in the provided evidence.
  • However, studies on the supplementation of these nutrients during pregnancy and their general safety profiles can provide some insights:
    • Magnesium supplementation during pregnancy was found to have no significant difference in perinatal mortality, small-for-gestational age, or pre-eclampsia compared to no magnesium supplementation 2.
    • Riboflavin (B2) has been recommended for migraine prevention in adults with minimal adverse events, but its safety in pediatric use and during lactation is not well established 3.
    • Coenzyme Q10 has been found to have low adverse events and Level C evidence for migraine prevention, but its safety during lactation is not directly addressed in the provided studies 3, 4.
  • It is essential to note that the safety of these nutrients during lactation may depend on various factors, including the dosage and individual circumstances.
  • Further research is needed to determine the safety and efficacy of multiple-micronutrient supplementation, including magnesium, riboflavin (B2), and coenzyme Q10, during lactation 5.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Magnesium supplementation in pregnancy.

The Cochrane database of systematic reviews, 2014

Research

Coenzyme Q10 supplementation: Efficacy, safety, and formulation challenges.

Comprehensive reviews in food science and food safety, 2020

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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