From the Guidelines
The maintenance dose of thiamine (Vitamin B1) should be 1.1-1.2 mg/day for adults, as recommended by the RDAs, to ensure adequate intake and prevent deficiency 1. When considering the maintenance dose of thiamine, it's essential to look at the recommended dietary allowances (RDAs) and estimated average requirements (EARs).
- The RDAs for adults are 1.1-1.2 mg/day, which is the recommended intake to meet the needs of most individuals 1.
- The EARs for adults are 0.9-1.0 mg/day, but the RDAs are set higher to account for individual variability and ensure adequate intake 1.
- In certain situations, such as parenteral nutrition (PN), higher doses of 2-6 mg/day may be recommended, but for general maintenance, the RDA is sufficient 1.
- It's also important to note that the half-life of thiamine is relatively short, and insufficient dietary intake can quickly lead to deficiency, especially in critical illness or with increased metabolic needs 1.
- The main nutritional sources of thiamine, such as whole grains, legumes, meats, nuts, and fortified foods, should be encouraged to maintain adequate intake 1.
- In clinical practice, it's crucial to prioritize the RDA of 1.1-1.2 mg/day to prevent thiamine deficiency and its associated complications, such as Wernicke encephalopathy, Korsakoff syndrome, or beriberi 1.
From the FDA Drug Label
DOSAGE AND ADMINISTRATION: ... An oral therapeutic multivitamin preparation containing 5 mg to 10 mg thiamine, administered daily for one month, is recommended to achieve body tissue saturation. OVERDOSAGE: ... However, dosages exceeding 30 mg three times a day are not utilized effectively.
The maintenance dose of thiamine is not explicitly stated, but based on the information provided, 5 mg to 10 mg of thiamine per day is recommended to achieve body tissue saturation 2. Additionally, it is noted that dosages exceeding 30 mg three times a day are not utilized effectively 2.
From the Research
Maintenance Dose of Thiamine
The maintenance dose of thiamine (Vitamin B1) varies depending on the patient's condition and risk of deficiency.
- For patients with established Wernicke's encephalopathy, the maintenance dose is oral thiamine 250-1000mg/day 3.
- For patients with suspected Wernicke's encephalopathy, the maintenance dose is oral thiamine 250-300mg/day 3.
- For patients at high risk of thiamine deficiency, the maintenance dose is oral thiamine 250-300mg/day 3.
- For patients at low risk (with uncomplicated alcohol dependence), the maintenance dose is oral thiamine 100-250mg/day 3.
- For patients receiving long-term home parenteral nutrition, a daily dose of 3 mg of thiamine hydrochloride is sufficient to maintain normal thiamine status 4.
- For patients with type 2 diabetes, thiamine supplementation does not affect glycaemic outcomes, and the optimal dose is not established 5.
Special Considerations
- The dose of thiamine may need to be adjusted based on individual patient needs and response to treatment.
- Thiamine supplementation has been shown to improve clinical outcomes in patients with genetic defects of thiamine transport and metabolism 6.