What is the treatment for Hand, Foot, and Mouth Disease (HFMD)?

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Last updated: May 13, 2025View editorial policy

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From the Research

Hand, foot, and mouth disease is typically treated with supportive care as it's a viral infection that usually resolves on its own within 7-10 days. For symptom relief, take over-the-counter pain relievers like acetaminophen (Tylenol) at 325-650mg every 4-6 hours or ibuprofen (Advil, Motrin) at 200-400mg every 6-8 hours to reduce fever and pain 1.

Key Considerations

  • Stay hydrated by drinking plenty of fluids, especially cold liquids that may soothe throat pain.
  • Avoid spicy, acidic, or hot foods that can irritate mouth sores.
  • Salt water rinses (1/2 teaspoon salt in 1 cup warm water) can help relieve mouth pain.
  • For painful mouth sores, topical oral anesthetics like benzocaine (Orajel) can provide temporary relief.
  • Rest is important for recovery.
  • Practice good hygiene by washing hands frequently and avoiding close contact with others to prevent spreading the virus.

Prevention and Complications

  • The disease is most contagious during the first week but can remain in the body for weeks after symptoms disappear.
  • If symptoms worsen significantly, if there's severe dehydration, or if symptoms don't improve after 10 days, medical attention should be sought 2, 1.
  • In severe cases, intravenous immunoglobulin may be considered for treatment 1.
  • Vaccination and good personal hygiene are important preventative measures to combat the disease 3, 4.

References

Research

Hand, Foot, and Mouth Disease: A Narrative Review.

Recent advances in inflammation & allergy drug discovery, 2022

Research

Hand-Foot-and-Mouth Disease: Rapid Evidence Review.

American family physician, 2019

Research

Hand, foot and mouth disease: current knowledge on clinical manifestations, epidemiology, aetiology and prevention.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2018

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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