From the Research
Singular (montelukast) should be stopped before allergy testing to ensure accurate results, as it may suppress skin test responses and lead to false-negative results. The most recent and highest quality study, 1, published in 2022, compared the efficacy of montelukast and azelastine add-on therapy in moderate to severe allergic rhinitis treatment, but did not specifically address the issue of stopping montelukast before allergy testing. However, based on the mechanism of action of montelukast as a leukotriene receptor antagonist, it is likely to affect skin test responses.
- Unlike antihistamines, which typically need to be stopped 3-7 days before testing, leukotriene modifiers like Singular have a different mechanism of action but can still affect test accuracy.
- It is recommended to discontinue Singular for at least 5-7 days prior to skin testing for allergies, but the exact duration may vary depending on individual circumstances.
- The decision to stop Singular before allergy testing should be made in consultation with a healthcare provider, who can weigh the potential benefits and risks of discontinuing the medication and determine the best course of action for each patient.
- Some providers might have different protocols regarding Singular discontinuation before testing, and in some cases, they might determine that the benefits of continuing the medication outweigh the potential impact on test results, as seen in studies such as 2, 3, and 4.