From the Guidelines
Two short PR syndromes are Wolff-Parkinson-White (WPW) syndrome and Lown-Ganong-Levine (LGL) syndrome. These conditions involve abnormal electrical conduction pathways in the heart that bypass the normal conduction delay at the atrioventricular (AV) node, resulting in a shortened PR interval on electrocardiogram (ECG) 1. In WPW syndrome, patients have a short PR interval plus a delta wave (slurred upstroke of the QRS complex) and widened QRS complexes, resulting from an accessory pathway called the Kent bundle that connects the atria directly to the ventricles. LGL syndrome presents with a short PR interval with normal QRS complexes, caused by an accessory pathway called the James fiber that connects the atria directly to the His bundle 1. Some key points to consider in these conditions include:
- Abnormal electrical conduction pathways in the heart
- Shortened PR interval on ECG
- Accessory pathways (Kent bundle or James fiber) that bypass the normal conduction delay at the AV node
- Potential for episodes of tachycardia and serious arrhythmias
- Management options ranging from observation to antiarrhythmic medications to catheter ablation of the accessory pathway in symptomatic cases. It's worth noting that while Turner syndrome is mentioned in the provided evidence, it is not directly related to short PR syndromes, and therefore, is not relevant to this specific question 1.
From the Research
Short PR Syndromes
Two short PR syndromes are:
- Lown-Ganong-Levine (LGL) syndrome, a rare pre-excitation disorder associated with paroxysmal tachyarrhythmias, characterized by short PR intervals 2, 3, 4
- Wolff-Parkinson-White syndrome, another pre-excitation disorder that can cause supraventricular tachycardia, also associated with short PR intervals and abnormal atrial depolarization patterns 3, 4
Key Characteristics
Some key characteristics of these syndromes include: