From the Research
Magnesium glycinate is not a recommended treatment for dyskinesias based on the most recent and highest quality study available, which suggests that globus pallidus interna deep brain stimulation (GPi-DBS) may be the most effective therapy for treating dyskinesia 1.
Introduction to Dyskinesias Treatment
When considering treatment options for dyskinesias, it's essential to prioritize morbidity, mortality, and quality of life as outcomes. The most recent study from 2025, a network meta-analysis of randomized controlled trials, provides the strongest evidence for guiding treatment decisions 1.
Current Recommendations
Based on the 2025 study, the following treatments are significantly more effective in reducing dyskinesias than control:
- Globus pallidus interna deep brain stimulation (GPi-DBS)
- Levodopa-carbidopa intestinal gel infusion
- Subthalamic nucleus (STN)-DBS
- Immediate-release (IR) amantadine
- Pallidotomy
- ADS-5102
- Clozapine
- OS320
- AFQ056
Magnesium Glycinate Considerations
While magnesium glycinate may have potential benefits for muscle relaxation and neurological function, its effectiveness in managing dyskinesias is not supported by the most recent and highest quality study 1. Therefore, it is not a recommended treatment option.
Clinical Considerations
Before starting any treatment, it's crucial to consult with a healthcare provider, especially if you have kidney disease, heart conditions, or take medications that might interact with the recommended treatments. Maintaining adequate hydration and monitoring for improvement are also essential aspects of treatment. If no benefit is observed after 4-6 weeks, discussing alternative treatments with your doctor is necessary.