What is the significance of a white blood cell (WBC) count of 10.9 x10E3/uL, which is higher than the normal range of 3.4-10.8 x10E3/uL, and an elevated lymphocyte (Lymphs) absolute count of 3.9 x10E3/uL, which is higher than the normal range of 0.7-3.1 x10E3/uL?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 13, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis

The patient's laboratory results show a slightly elevated white blood cell (WBC) count with a left shift noted on the blood smear, indicating the presence of immature cells. The absolute lymphocyte count is also elevated. Based on these findings, the following differential diagnoses are considered:

  • Single Most Likely Diagnosis
    • Viral Infection: The elevated WBC count with a left shift and increased absolute lymphocyte count suggests a viral infection, such as mononucleosis or a viral upper respiratory tract infection. The presence of immature cells on the blood smear further supports this diagnosis.
  • Other Likely Diagnoses
    • Bacterial Infection: A bacterial infection, such as pneumonia or a urinary tract infection, could also cause an elevated WBC count with a left shift. However, the elevated absolute lymphocyte count is more suggestive of a viral infection.
    • Inflammatory Condition: An inflammatory condition, such as rheumatoid arthritis or inflammatory bowel disease, could cause an elevated WBC count. However, the presence of immature cells on the blood smear is more suggestive of an infectious process.
  • Do Not Miss Diagnoses
    • Leukemia: Although the patient's WBC count is only slightly elevated, the presence of immature cells on the blood smear could suggest a hematologic malignancy, such as leukemia. This diagnosis would be life-threatening if missed, and further evaluation, including a bone marrow biopsy, would be necessary to rule it out.
    • Sepsis: Sepsis is a life-threatening condition that could cause an elevated WBC count with a left shift. Although the patient's vital signs are not provided, sepsis should be considered as a potential diagnosis, especially if the patient is showing signs of systemic illness.
  • Rare Diagnoses
    • Lymphoma: A lymphoma, such as Hodgkin's or non-Hodgkin's lymphoma, could cause an elevated WBC count with an increased absolute lymphocyte count. However, this diagnosis would be less likely without other supporting evidence, such as lymphadenopathy or splenomegaly.
    • Myeloproliferative Neoplasm: A myeloproliferative neoplasm, such as polycythemia vera or essential thrombocytosis, could cause an elevated WBC count. However, these conditions are typically associated with other abnormalities, such as an elevated hematocrit or platelet count, which are not present in this patient's laboratory results.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.