From the Research
Magnesium may be beneficial in reducing stimulant-induced dyskinesia, as evidenced by its ability to prevent and reverse movement disturbances in animal models, as shown in a study published in 2017 1. The potential benefits of magnesium in treating stimulant-induced dyskinesia can be attributed to its role as an NMDA receptor antagonist and calcium channel blocker, which could theoretically reduce abnormal movements caused by stimulants like amphetamines or cocaine. Some key points to consider when using magnesium for stimulant-induced dyskinesia include:
- Magnesium supplements, typically 300-400mg of elemental magnesium daily, divided into doses, might be worth trying alongside proper medical treatment.
- Common forms of magnesium, such as magnesium glycinate, citrate, or malate, are generally better absorbed than magnesium oxide.
- Magnesium works by stabilizing neuronal excitability and modulating dopamine transmission, potentially counteracting the dopamine dysregulation caused by stimulants.
- Side effects of magnesium supplementation are usually mild and include digestive issues like diarrhea.
- It's essential to consult with a healthcare provider before starting magnesium, especially if you have kidney problems or take medications that might interact with it, as noted in a study published in 2015 2. The most recent and highest quality study on this topic, published in 2017 1, suggests that magnesium supplementation may be a useful alternative to prevent movement disturbances resulting from classic antipsychotic pharmacotherapy, which could be applicable to stimulant-induced dyskinesia as well. However, it's crucial to prioritize conventional treatments like dose reduction of the stimulant or antipsychotic medications that your doctor might prescribe, as magnesium should not replace these treatments. Additionally, a study published in 2020 3 highlights the importance of monitoring for dyskinesia in patients treated with stimulants, which further supports the potential benefits of magnesium in reducing stimulant-induced dyskinesia.