What is the cause of recurrent rectal bleeding upon defecation in a 25-year-old male with a history of anal fissure repair and colectomy (removal of the large intestine) due to Clostridioides difficile (C-diff) infection at age 2?

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Differential Diagnosis for Rectal Bleeding in a 25-year-old Male Patient

Single Most Likely Diagnosis

  • Anal Fissure: Given the patient's history of a previously diagnosed and treated anal fissure, which required stitching, it is likely that the current symptoms could be due to a recurrence of this condition. The patient's symptoms of bleeding upon wiping after defecation are consistent with an anal fissure.

Other Likely Diagnoses

  • Hemorrhoids: These are common causes of rectal bleeding, especially in individuals with a history of straining during bowel movements or constipation. The patient's previous surgery and potential for altered bowel habits could predispose him to hemorrhoids.
  • Proctitis: Inflammation of the rectum could be a cause of bleeding, especially considering the patient's history of C-difficile infection and subsequent large intestine removal. This could lead to chronic changes or inflammation in the remaining rectal tissue.

Do Not Miss Diagnoses

  • Colorectal Cancer: Although rare in young individuals, a history of significant gastrointestinal surgery and potential chronic inflammation could increase the risk. It is crucial to rule out cancer due to its severe implications.
  • Inflammatory Bowel Disease (IBD): Conditions like Crohn's disease or ulcerative colitis could cause rectal bleeding. The patient's history of C-difficile and surgical removal of the large intestine might increase the risk or complicate the diagnosis of IBD.
  • Gastrointestinal Infection: Recurrence of C-difficile or other gastrointestinal infections could cause rectal bleeding, especially in someone with a history of such infections and significant gastrointestinal surgery.

Rare Diagnoses

  • Angiodysplasia: A vascular anomaly of the gastrointestinal tract that could cause bleeding. It is less common and typically seen in older adults but should be considered in the differential diagnosis due to the patient's complex medical history.
  • Solitary Rectal Ulcer Syndrome: A condition that can cause rectal bleeding, typically associated with chronic constipation and straining during bowel movements. It might be considered given the patient's history and potential for altered bowel habits.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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