What is the anatomical location where Nexplanon (etonogestrel) is typically inserted?

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Last updated: May 14, 2025View editorial policy

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From the Guidelines

Nexplanon is placed in the inside of the nondominant upper arm, 6 to 8 cm above the elbow, by a medical professional who has completed the requisite training. This location is ideal for the implant as it allows for easy insertion and removal, while minimizing the risk of complications such as nerve injury or damage to major blood vessels. The implant is inserted subdermally, just under the skin but above the muscle layer, which enables steady release of hormones into the bloodstream while keeping the device secure 1. Key considerations for the placement of Nexplanon include:

  • The implant should be inserted in the nondominant arm to minimize discomfort and interference with daily activities
  • The location 6 to 8 cm above the elbow is chosen to avoid major blood vessels, nerves, and tendons
  • The subdermal placement allows for easy palpation and verification of the implant's presence by healthcare providers
  • The use of local anesthetic and a special applicator ensures a relatively painless and quick insertion process, taking approximately 1 minute 1.

From the Research

Area of Nexplanon Placement

The area where Nexplanon is typically placed is:

  • The inner side of the upper non-dominant arm, approximately 8-10 cm above the medial epicondyle of the humerus 2
  • The medial side of the non-dominant upper arm 3
  • Subdermally, superficial to the triceps muscle, to lower the risk of insertion into vessels and nerves 2

Characteristics of Nexplanon Placement

Key characteristics of Nexplanon placement include:

  • The implant is a 4 cm rod-shaped barium sulphate coated contraceptive implant 4
  • It is intended to be placed subdermally, with the insertion site usually being on the inner non-dominant upper arm 4, 3, 2
  • The implant is not biodegradable and must be removed after its licensed duration 3

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Migration of a subdermal contraceptive implant into a subsegmental pulmonary artery and etonogestrel serum concentration over time - a case report.

The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception, 2022

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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