From the Guidelines
Patients taking Entyvio (vedolizumab) should be monitored for vitamin B12 deficiency and may require supplementation, as the medication can potentially interfere with vitamin B12 absorption in the terminal ileum. To prevent deficiency:
- Check vitamin B12 levels before starting Entyvio and periodically during treatment, as recommended by the most recent guidelines 1.
- If deficient, supplement with oral vitamin B12 1000-2000 mcg daily or intramuscular injections of 1000 mcg monthly, based on the latest evidence 1.
- For patients with normal levels, consider preventive supplementation with oral vitamin B12 500-1000 mcg daily, although the optimal dosage is still being explored 1. Vitamin B12 is crucial for nerve function and red blood cell production, and deficiency can lead to anemia and neurological symptoms. Entyvio's mechanism of action in the gut may reduce B12 absorption, making monitoring and supplementation important for patients on this medication. If symptoms of B12 deficiency develop (fatigue, weakness, numbness/tingling), promptly assess levels and adjust supplementation as needed, taking into account the patient's individual risk factors and medical history, as emphasized in recent studies 1, 2. Patients with a history of B12 deficiency or ileal resection may require more aggressive supplementation or monitoring, as highlighted in the latest guidelines 1.
From the Research
Relationship Between Vitamin B12 Deficiency and Entyvio (Vedolizumab) Treatment
There is no direct evidence in the provided studies that discusses the relationship between Vitamin B12 deficiency and treatment with Entyvio (vedolizumab).
Vitamin B12 Deficiency Diagnosis and Treatment
- The diagnosis of Vitamin B12 deficiency can be established through clinical symptoms, laboratory biomarkers, and response to treatment 3, 4, 5, 6.
- Serum B12 concentration, methylmalonic acid, and homocysteine levels can be used as screening markers and to support the diagnosis 4, 5.
- Treatment options for Vitamin B12 deficiency include parenteral and oral supplementation, with oral supplementation being as effective as parenteral administration in some cases 4, 7, 5.
- The choice of treatment route and dose depends on the severity of clinical symptoms, the cause of the deficiency, and treatment goals 4.
Entyvio (Vedolizumab) and Vitamin B12 Deficiency
- There are no research papers provided that discuss the relationship between Entyvio (vedolizumab) treatment and Vitamin B12 deficiency.
- The provided studies focus on the diagnosis, treatment, and management of Vitamin B12 deficiency, but do not mention Entyvio (vedolizumab) or its potential impact on Vitamin B12 levels 3, 4, 7, 5, 6.