From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
The estradiol level of 310 pmol/L is within the normal range for perimenopausal and postmenopausal women using transdermal estradiol, as defined by a reference interval of 54.62-2,050.55 pmol/L 1. This value indicates appropriate estrogen production for women on hormone replacement therapy.
- No specific intervention is needed if this result is from a woman of reproductive age with regular menstrual cycles.
- However, interpretation depends on the clinical context, including age, menstrual status, and any hormone therapy.
- For postmenopausal women, this level would be considered therapeutic and might not warrant further investigation.
- For men, this would be considered high and could indicate conditions like gynecomastia, liver disease, or certain tumors.
- If you're taking hormone replacement therapy, this level suggests adequate dosing, but dose customization is key to ensure that all women can reap the benefits of hormone therapy 1.
- If you're experiencing symptoms despite this normal level, other hormones like progesterone or testosterone might need evaluation.
- Regular monitoring is recommended if you're on hormone therapy, with testing typically done at the same time in your cycle for consistent results.
- It's also important to note that serum estradiol levels can vary significantly between individuals, and measurement of serum estradiol can be helpful to identify women who may benefit from an off-label dose 1.