From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
For male UTIs, the best antibiotic is typically nitrofurantoin at a dose of 100 mg four times daily for 7 days, as it has a favorable resistance profile and is effective in treating uncomplicated UTIs, as shown in a recent study 1. When considering treatment options for male UTIs, it's essential to take into account the potential for antibiotic resistance and the effectiveness of different antibiotics in penetrating prostate tissue.
- Nitrofurantoin is a suitable option for uncomplicated UTIs, with a low resistance rate of 10.3% 1.
- Fluoroquinolones, such as ciprofloxacin and levofloxacin, have high resistance rates and are not ideal empiric antibiotics for treatment of outpatient UTI in certain regions 1.
- Trimethoprim-sulfamethoxazole (TMP-SMX) also has a high resistance rate and may not be the best option for empiric treatment 1.
- Amoxicillin/clavulanate and 2nd and 3rd generation cephalosporins may be acceptable alternatives, given their lower resistance rates and effectiveness in treating UTIs 1. It's crucial to note that the choice of antibiotic should be guided by local resistance patterns and patient-specific factors, such as recent antibiotic use or complicated infections.
- A urine culture should be obtained to confirm the infection and guide therapy if the empiric treatment fails.
- Symptoms should improve within 48-72 hours of starting antibiotics, and increased fluid intake and completing the full antibiotic course are essential for effective treatment. The most recent and highest quality study 1 provides the best evidence for guiding treatment decisions in male UTIs, and its findings should be prioritized when selecting an antibiotic.