Differential Diagnosis for Mono Screen Negative, but EBV Early Antigen D IgG Positive
- Single Most Likely Diagnosis
- Past EBV infection: This is the most likely diagnosis because the presence of EBV early antigen D IgG indicates a past infection. The mono screen being negative suggests that the patient is not currently infected with EBV.
- Other Likely Diagnoses
- Chronic EBV infection: Although less common, some individuals may have a chronic EBV infection, which could explain the positive IgG result.
- False-negative mono screen: It's possible that the mono screen was a false negative, and the patient may still have an active EBV infection.
- Do Not Miss Diagnoses
- Burkitt lymphoma: Although rare, Burkitt lymphoma is associated with EBV infection, and a positive IgG result could be a clue to this diagnosis. Missing this diagnosis could be deadly.
- Nasopharyngeal carcinoma: This rare cancer is also associated with EBV infection, and a positive IgG result could be a red flag.
- Rare Diagnoses
- EBV-associated hemophagocytic lymphohistiocytosis (HLH): This rare and potentially life-threatening condition is associated with EBV infection.
- X-linked lymphoproliferative disease (XLP): A rare genetic disorder that affects the immune system's response to EBV infection, leading to severe complications.