From the Research
Tesamorelin should be used 5 days a week, as this schedule helps prevent desensitization to the medication's effects and aligns with its typical dosing guidelines of 1-2 mg per day via subcutaneous injection. The medication works by stimulating growth hormone release from the pituitary gland, and continuous daily use without breaks may lead to diminished effectiveness over time as the body adapts to constant stimulation 1, 2. When using tesamorelin, injections should be given at the same time each day, preferably before bedtime to align with the body's natural growth hormone release patterns. The injection site should be rotated regularly to prevent localized reactions. Users should store reconstituted tesamorelin in the refrigerator and use within 24 hours. This medication is primarily prescribed for reducing excess abdominal fat in HIV patients with lipodystrophy, though it's sometimes used off-label for anti-aging purposes. Some key points to consider when using tesamorelin include:
- The importance of regular monitoring for side effects, which may include injection site reactions, joint pain, and potential impacts on glucose metabolism 3, 4
- The need for patients to be aware of the potential for desensitization to the medication's effects if used continuously without breaks 5
- The medication's efficacy in reducing visceral adipose tissue and improving body image in patients with HIV-associated lipodystrophy, as demonstrated in clinical trials 1, 2, 4