Is Epo (Erythropoietin) used to treat breast pain?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 15, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Research

Evening primrose oil (EPO) is recommended for treating breast pain, specifically cyclical mastalgia, as it has been shown to be effective in reducing breast pain severity. Breast pain, also called mastalgia, is typically managed with other approaches including over-the-counter pain relievers like ibuprofen (200-400mg every 4-6 hours) or acetaminophen (500-1000mg every 4-6 hours), well-fitted supportive bras, warm or cold compresses, and lifestyle modifications such as reducing caffeine intake. For moderate to severe cases, prescription options might include topical NSAIDs, hormonal treatments like oral contraceptives, or in specific cases, prescription medications such as tamoxifen (10-20mg daily). The use of EPO for breast pain is supported by a study published in 2024 1, which found that the combination of EPO and vitamin E demonstrated superior efficacy in reducing breast pain severity compared with individual treatments and placebo. Key points to consider when treating breast pain include:

  • EPO is not a hormone that stimulates red blood cell production, but rather evening primrose oil, which is a different substance.
  • The evidence for EPO in treating breast pain is based on its anti-inflammatory and hormonal effects.
  • Other treatments, such as tamoxifen, may also be effective for breast pain, but may have more side effects 2.
  • It is essential to consult with a healthcare provider for proper evaluation and appropriate treatment recommendations tailored to your specific situation. In terms of the quality of life, breast pain can significantly impact daily living, and finding an effective treatment is crucial 3. Overall, EPO is a viable treatment option for breast pain, particularly cyclical mastalgia, and should be considered in conjunction with other management strategies.

Related Questions

What is the recommended dose of evening primrose oil (EPO) for the treatment of mastalgia (breast pain)?
Is primrose oil effective for treating mastalgia in postmenopausal women with normal breast imaging?
What are the next steps for a 30-year-old female presenting with 1-2 weeks of bilateral dull/achy breast pain at the lateral aspect and inner, upper portions, occurring daily without correlation to her menstrual cycle, and without skin changes or palpable lumps?
What could be causing intermittent spotting and intermittent right breast ache?
What is the next best step for a 30-year-old patient with cyclic mastalgia (breast tenderness) and a firm breast swelling that persists after menstruation, given a normal breasting examination (NBE)?
Can rupatadine (Rupatadine) be used to treat allergy in a patient with Crohn's disease?
What is the preference between Methylprednisolone (Solumedrol) or Hydrocortisone (Solucortef) for patients on Prednisone?
How to diagnose a prolonged PR interval (P wave to R wave interval)?
Can exposure to sulfur mustard, organophosphate (OP) chlorides, combustion products, fuel vapors, ionizing radiation, and non-ionizing (exciting) radiation cause chronic vertigo?
What is the appropriate dose of amoxicillin (Amox) for a 10-year-old male weighing 65 pounds with an ear infection, given a dosage of 90 milligrams per kilogram per day?
Is increased ossific density at the lateral aspect of the fifth metatarsal (metatarsal bone) base more likely to represent an apophysis (growth plate) rather than an avulsion fracture?

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.