From the Research
Tirzepatide can cause palpitations in some patients, though it's not among the most common side effects. Palpitations (feelings of rapid, fluttering, or pounding heartbeat) have been reported by some people taking tirzepatide (brand names Mounjaro and Zepbound), which is used to treat type 2 diabetes and obesity. These heart rhythm disturbances typically occur during the initial weeks of treatment or after dose increases. The mechanism likely relates to tirzepatide's effects on the GLP-1 and GIP receptors, which can influence heart rate and blood pressure 1.
Key Points to Consider
- The incidence of palpitations with tirzepatide is not well-established in the provided studies, but it is mentioned as a potential side effect in the context of its effects on heart rate and blood pressure 2.
- Tirzepatide has been shown to have significant cardiovascular benefits, including reducing the risk of major adverse cardiovascular events (MACE) 3.
- The medication's effects on heart failure outcomes have also been investigated, with real-world data suggesting a potential therapeutic benefit in managing heart failure without diabetes 4.
- If you experience persistent or severe palpitations while taking tirzepatide, you should contact your healthcare provider promptly. They may recommend monitoring your heart rhythm, adjusting your dose, or in some cases, switching to an alternative medication.
Recommendations for Patients
- Maintain adequate hydration to minimize the risk of dehydration, which can worsen palpitations.
- Be mindful of other triggers that can exacerbate palpitations, such as caffeine intake or anxiety.
- Regularly monitor your heart rhythm and report any concerns to your healthcare provider.
- Follow the prescribed dosage and treatment plan to minimize the risk of side effects, including palpitations 5.