What is the cause of my nocturnal enuresis, where I sleep through and do not feel the urge to urinate?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 16, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Nocturnal Enuresis

The patient's complaint of peeing the bed without feeling the urge to urinate suggests a range of possible causes. Here's a categorized differential diagnosis:

  • Single most likely diagnosis

    • Nocturnal Enuresis (Bedwetting): This condition is characterized by involuntary urination during sleep, often without the individual being aware of the need to urinate. It's a common issue, especially in children, but can also occur in adults due to various factors such as genetics, bladder control issues, or sleep patterns.
  • Other Likely diagnoses

    • Sleep Disorders: Conditions like sleep apnea, insomnia, or restless leg syndrome can disrupt normal sleep patterns, leading to a decreased awareness of the need to urinate.
    • Urinary Tract Infections (UTIs): UTIs can cause irritation to the bladder, leading to frequent or involuntary urination.
    • Diabetes: Uncontrolled diabetes can lead to increased urine production, potentially resulting in nocturnal enuresis.
    • Neurological Conditions: Certain conditions, such as multiple sclerosis, Parkinson's disease, or spinal cord injuries, can affect bladder control.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)

    • Diabetes Insipidus: A rare condition characterized by the inability to regulate fluids in the body, leading to excessive urine production.
    • Sleep Apnea with Associated Cardiac Conditions: Untreated sleep apnea can increase the risk of cardiac problems, such as heart failure or arrhythmias.
    • Neurogenic Bladder due to Spinal Cord Injury or Tumor: A spinal cord injury or tumor can cause bladder control issues, and prompt diagnosis is crucial to prevent further complications.
  • Rare diagnoses

    • Nocturnal Seizures: In rare cases, nocturnal seizures can cause involuntary urination.
    • Bladder Cancer or Stones: Although rare, bladder cancer or stones can cause irritation and lead to nocturnal enuresis.
    • Hormonal Imbalances: Certain hormonal imbalances, such as those caused by a pituitary gland disorder, can affect bladder control.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.