Differential Diagnosis for African American Female with 4.0 WBC, Absolute Neutrophil Count 1L, and Absolute Basophil Count 1.7
- Single Most Likely Diagnosis
- Chronic Myeloid Leukemia (CML): The elevated absolute basophil count is a key finding, as basophilia is a characteristic feature of CML. Although the white blood cell count (WBC) is not markedly elevated, CML can present with a wide range of WBC counts.
- Other Likely Diagnoses
- Myeloproliferative Neoplasm (MPN): The presence of basophilia and a low absolute neutrophil count could be seen in other MPNs, such as polycythemia vera or primary myelofibrosis, although these conditions are less likely to present with significant basophilia.
- Leukemoid Reaction: A reactive process that can mimic leukemia, often seen in response to infection, inflammation, or other stressors. However, the presence of basophilia is less common in leukemoid reactions.
- Do Not Miss Diagnoses
- Acute Myeloid Leukemia (AML): Although less likely given the relatively low WBC count and the presence of basophilia, AML is a potentially life-threatening condition that requires prompt diagnosis and treatment.
- Severe Infection or Sepsis: A low absolute neutrophil count can indicate severe infection or sepsis, which would require immediate attention and treatment.
- Rare Diagnoses
- Basophilic Leukemia: A rare form of leukemia characterized by the proliferation of basophilic cells. It is often associated with a poor prognosis.
- Mastocytosis: A condition characterized by the accumulation of mast cells in various tissues, which can occasionally present with basophilia. However, this diagnosis is less likely given the clinical presentation and laboratory findings.