From the FDA Drug Label
Intractable Hiccups– 25 mg to 50 mg t.i.d. or q.i.d. If symptoms persist for 2 to 3 days, parenteral therapy is indicated. The best way to treat hiccups is with chlorpromazine (PO) at a dosage of 25 mg to 50 mg taken three or four times a day. If symptoms persist for 2 to 3 days, parenteral therapy is indicated 1.
From the Research
The best way to treat hiccups is to try simple home remedies first, such as stimulating the vagus nerve by gargling with ice water, placing a cold compress on the face, or performing a Valsalva maneuver, as most hiccup episodes resolve on their own within a few minutes 2. When considering treatment options, it's essential to prioritize methods that minimize morbidity, mortality, and impact on quality of life.
- Simple home remedies, such as drinking a glass of cold water quickly, holding breath for 10-20 seconds, or breathing into a paper bag, can be effective in stopping hiccups.
- For persistent hiccups lasting more than 48 hours, medical treatment may be necessary, and medications like baclofen (5-10 mg three times daily), chlorpromazine (25-50 mg), or metoclopramide (10 mg) can be considered 3.
- Recent studies have also explored the use of acupuncture as a potential treatment option for persistent and intractable hiccups, with some evidence suggesting its efficacy and safety 4, 5.
- The role of serotonin in singultus has also been investigated, with research suggesting that serotonin receptor subtype ligands may have a beneficial effect on hiccup treatment 6.
- It's crucial to note that while these treatment options are available, the most recent and highest-quality study should be prioritized when making a definitive recommendation, and in this case, the study on vagus nerve stimulation for intractable hiccups provides valuable insights into the treatment of this condition 2.