What are the differential diagnoses for a biceps tendon rupture?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 17, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Biceps Tendon Rupture Differential Diagnosis

When considering a differential diagnosis for a biceps tendon rupture, it's essential to evaluate various conditions that could mimic or be associated with this injury. The following categories help organize potential diagnoses:

  • Single Most Likely Diagnosis

    • Biceps tendon rupture itself is the most likely diagnosis when a patient presents with symptoms such as a sudden, severe pain in the upper arm, a "pop" sound at the time of injury, swelling, bruising, and a visible bulge in the upper arm (Popeye deformity). This condition typically occurs due to overuse or direct trauma to the biceps tendon.
  • Other Likely Diagnoses

    • Tendinitis of the biceps tendon: Inflammation of the biceps tendon can cause pain and weakness in the shoulder and elbow, similar to a rupture. It often results from overuse or repetitive strain.
    • Strain of the biceps muscle: A strain or pull in the biceps muscle can mimic some symptoms of a tendon rupture, including pain and weakness, but typically without the characteristic deformity.
    • Dislocation or subluxation of the shoulder: Although primarily affecting the shoulder joint, a dislocation can also cause biceps tendon instability or injury, presenting with overlapping symptoms.
    • Rotator cuff injury: Tears or strains in the rotator cuff muscles can cause shoulder pain and weakness, potentially mimicking some symptoms of a biceps tendon rupture.
  • Do Not Miss Diagnoses

    • Brachial plexus injury: A severe injury to the brachial plexus can cause significant arm weakness, pain, and numbness. While less common, missing this diagnosis could lead to permanent neurological damage.
    • Fracture of the humerus or radius: A fracture in the upper arm or forearm could present with pain and swelling similar to a biceps tendon rupture and must be ruled out to avoid missing a potentially serious condition requiring immediate intervention.
    • Vascular injury: Damage to the blood vessels in the arm could lead to severe complications, including limb ischemia. Symptoms might include coldness, pallor, pulselessness, poikilothermia, pain, paresthesias, and paralysis.
  • Rare Diagnoses

    • Infectious tenosynovitis: An infection of the tendon sheath, which could cause pain, swelling, and redness similar to a rupture, but is less common and typically associated with systemic signs of infection.
    • Tumor of the biceps tendon or surrounding tissues: Although extremely rare, tumors could cause chronic pain and swelling, potentially mimicking a tendon rupture.
    • Rheumatologic conditions affecting tendons: Certain autoimmune diseases can cause tendon inflammation and rupture, presenting similarly to a traumatic biceps tendon rupture.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.