From the Guidelines
Intraocular vitreous haematoma is primarily caused by retinal vein occlusion, diabetic retinopathy, and other conditions that damage blood vessels in the eye, leading to vision loss and morbidity. The causes of intraocular vitreous haematoma can be understood by examining the underlying conditions that lead to blood vessel damage in the eye. Some key causes include:
- Retinal vein occlusion, which occurs when there is a partial or complete obstruction of a retinal vein, leading to vision loss and potentially vitreous haematoma 1
- Diabetic retinopathy, where abnormal blood vessels grow and rupture in the retina, causing bleeding into the vitreous cavity
- Retinal tears or detachments that disrupt blood vessels, allowing blood to leak into the vitreous
- Posterior vitreous detachment, where the vitreous gel pulls away from the retina, potentially causing blood vessels to rupture
- Trauma to the eye, which can damage blood vessels and lead to haematoma
- Age-related macular degeneration with bleeding, where abnormal blood vessels grow and rupture, causing haematoma
- Vascular abnormalities like retinal vein occlusion, which can lead to haematoma due to the obstruction of blood flow 1 The severity of symptoms depends on the amount of bleeding, with patients typically experiencing sudden onset of floaters, blurred vision, or vision loss. Treatment depends on the underlying cause and may include observation for mild cases, laser therapy, anti-VEGF injections, or vitrectomy surgery to remove the blood if it doesn't clear naturally, with the goal of improving vision and reducing morbidity. It is essential to address the underlying cause of the haematoma to prevent further vision loss and improve patient outcomes, as highlighted in the study on retinal vein occlusions 1.
From the FDA Drug Label
The FDA drug label does not answer the question.
From the Research
Intraocular Vitreous Haematoma Causes
- Proliferative diabetic retinopathy is a common cause of vitreous hemorrhage, as reported in studies 2, 3, 4
- Trauma is also a significant cause of vitreous hemorrhage, as mentioned in studies 2, 3
- Retinal breaks and posterior vitreous detachment without retinal break can lead to vitreous hemorrhage, as stated in study 2
- Vascular occlusive disease, retinal arterial macroaneurysm, hemoglobinopathies, age-related macular degeneration, and intraocular tumors are less common causes of vitreous hemorrhage, as reported in study 3
- Retinal vein occlusion, perivenous retinitis, retinal tears/detachment, exudative AMD, and polypoidal choroidal vasculopathy are also etiologies of non-diabetic retinopathy and non-traumatic vitreous hemorrhage, as found in study 5
- Intravitreal anti-vascular endothelial growth factor (VEGF) therapy can cause vitreous hemorrhage as an adverse event, as mentioned in study 6