What are the FDA (Food and Drug Administration) indications for hyperbaric oxygen therapy?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 19, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Research

The FDA has approved hyperbaric oxygen therapy (HBOT) for specific medical conditions, including decompression sickness, arterial gas embolism, carbon monoxide poisoning, and others, as supported by recent reviews such as 1. These indications include:

  • Air or gas embolism
  • Carbon monoxide poisoning
  • Gas gangrene
  • Crush injury
  • Decompression sickness
  • Arterial insufficiencies (including central retinal artery occlusion)
  • Severe anemia
  • Intracranial abscess
  • Necrotizing soft tissue infections
  • Osteomyelitis (refractory)
  • Delayed radiation injury
  • Compromised skin grafts and flaps
  • Thermal burns

HBOT involves breathing pure oxygen in a pressurized chamber where atmospheric pressure is increased to 2-3 times normal levels, as described in 2 and 3. This allows the lungs to gather more oxygen than would be possible at normal air pressure, helping blood carry this extra oxygen throughout the body to fight bacteria and stimulate the release of growth factors and stem cells, which promote healing. Treatment protocols vary by condition but typically involve 90-120 minute sessions at pressures of 2.0-2.5 atmospheres absolute (ATA), with patients undergoing anywhere from 5 to 40 treatments depending on their specific condition and response to therapy, as indicated in 1. HBOT should be administered by trained medical professionals in certified facilities due to potential risks including ear and sinus pain, temporary nearsightedness, claustrophobia, and rarely, oxygen toxicity or lung damage. The use of HBOT in medical emergencies, including its development in various regions, has been discussed in studies such as 3, highlighting the importance of increased awareness and access to this therapy. Overall, HBOT is a valuable treatment option for various medical conditions, and its use should be considered based on the latest evidence and guidelines, such as those supported by 1.

References

Research

Adjunctive hyperbaric oxygen therapy in the treatment of thermal burns: a review.

Burns : journal of the International Society for Burn Injuries, 1994

Research

Hyperbaric oxygen therapy: its use in medical emergencies and its development in Hong Kong.

Hong Kong medical journal = Xianggang yi xue za zhi, 2018

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.