From the FDA Drug Label
Progesterone capsules contain the female hormone called progesterone. What is progesterone capsules used for? Treatment of Menstrual Irregularities Progesterone capsules are used for the treatment of secondary amenorrhea (absence of menstrual periods in women who have previously had a menstrual period) due to a decrease in progesterone When you do not produce enough progesterone, menstrual irregularities can occur. If your healthcare provider has determined your body does not produce enough progesterone on its own, progesterone capsules may be prescribed to provide the progesterone you need Protection of the Endometrium (Lining of the Uterus) Progesterone capsules are used in combination with estrogen-containing medications in a postmenopausal woman with a uterus (womb).
The function of progesterone is to:
- Treat menstrual irregularities, such as secondary amenorrhea, due to a decrease in progesterone
- Protect the endometrium (lining of the uterus) when used in combination with estrogen-containing medications in postmenopausal women with a uterus There is no information about luteal hormone in the provided drug label 1.
From the Research
Progesterone and luteinizing hormone (LH) are critical reproductive hormones with distinct functions in the body, with progesterone maintaining the uterine lining during the luteal phase and supporting pregnancy, and LH triggering ovulation and stimulating testosterone production in males. The function of these hormones is crucial for reproductive health, and their imbalance can lead to various issues, including infertility and menstrual irregularities. According to the most recent study 2, LH regulates inter-organelle communication and fate of the corpus luteum, which is essential for progesterone biosynthesis and maintenance of the corpus luteum. Some key points about these hormones include:
- Progesterone prepares the endometrium for implantation, decreases uterine contractions, and helps maintain pregnancy by supporting the placenta until it can produce sufficient hormones on its own.
- Luteinizing hormone triggers ovulation in females by causing the dominant follicle to release an egg, and in males, it stimulates Leydig cells in the testes to produce testosterone.
- Disruptions in either hormone can lead to menstrual irregularities, fertility problems, or hormonal imbalances requiring medical intervention, as noted in studies 3, 4, 5, 6. The complex feedback system involving these hormones and other reproductive hormones like estrogen and follicle-stimulating hormone regulates fertility and reproductive function, highlighting the importance of a balanced hormonal environment for reproductive health.