What is the equivalent dose of Mounjaro (tirzepatide) in milligrams for a patient taking 2 milligrams of Ozempic (semaglutide)?

From the Guidelines

The equivalent dose of Mounjaro (tirzepatide) for a patient taking 2 mg of Ozempic (semaglutide) would be approximately 10-15 mg, as indicated by the maximum dose range for Mounjaro 1. When converting from Ozempic to Mounjaro, it's essential to consider the distinct mechanisms of action, as Ozempic is a GLP-1 receptor agonist, while Mounjaro is a dual GIP/GLP-1 receptor agonist, which may provide enhanced glycemic control 1. Some key points to consider when making this conversion include:

• The 2 mg dose of Ozempic is the maximum approved dose for type 2 diabetes 1
• Mounjaro has a different pharmacokinetic profile, with a total dose range of 15 mg weekly 1
• The conversion is not precisely linear due to differences in potency and mechanism of action 1
• Patients should not make this switch without medical supervision, as the transition should be managed carefully with appropriate monitoring of blood glucose levels 1
• Side effects like nausea, vomiting, and diarrhea may occur during the transition, and dose adjustments might be necessary based on individual response 1.

From the Research

Conversion from Ozempic to Mounjaro

• The provided studies do not directly address the conversion from Ozempic (semaglutide) to Mounjaro (tirzepatide) in terms of dosage.
• However, the studies compare the efficacy and safety of tirzepatide and semaglutide in patients with type 2 diabetes and obesity 2, 3, 4, 5, 6.
• According to the study by 4, the maximum tolerated dose of tirzepatide was 10 mg or 15 mg, while the maximum tolerated dose of semaglutide was 1.7 mg or 2.4 mg.
• Since the patient is taking 2 mg of Ozempic, which is higher than the maximum tolerated dose of 1.7 mg or 2.4 mg mentioned in the study, a direct conversion to Mounjaro cannot be determined based on the provided evidence.
• Further research or consultation with a healthcare professional is necessary to determine the appropriate conversion from Ozempic to Mounjaro.

Key Findings

• Tirzepatide has been shown to be effective in reducing body weight and improving glycemic control in patients with type 2 diabetes and obesity 2, 3, 4, 5, 6.
• Semaglutide has also been shown to be effective in reducing body weight and improving glycemic control, but to a lesser extent than tirzepatide 2, 3, 4, 5, 6.
• The safety profiles of tirzepatide and semaglutide are similar, with gastrointestinal adverse events being the most common 2, 3, 4, 5, 6.