From the Guidelines
Taking amlodipine in the morning and lisinopril in the evening is not necessarily the most effective approach for managing hypertension, as the timing of antihypertensive medication dosing does not have a significant impact on blood pressure control, according to the most recent evidence 1. This is because the benefits of evening versus morning dosing of antihypertensive medications have not been consistently reproduced in subsequent trials 1. The key to effective blood pressure management is to take medications consistently at the same times each day, regardless of whether they are taken in the morning or evening. Some considerations for dosing schedule include:
- Amlodipine, a calcium channel blocker, has a long half-life of about 30-50 hours, providing consistent blood pressure control regardless of when it's taken.
- Lisinopril, an ACE inhibitor, can help control the natural rise in blood pressure that occurs in the early morning hours, but its efficacy is not significantly affected by the timing of dosing 1. It's essential to consult with a healthcare provider before adjusting any medication dosing schedule, as individual patient needs and responses to medication may vary 1. Ultimately, the goal of hypertension management is to reduce morbidity, mortality, and improve quality of life, and this can be achieved through consistent medication adherence and regular monitoring of blood pressure, rather than relying on a specific dosing schedule 1.
From the Research
Efficacy of Taking Amlodipine in the Morning and Lisinopril in the Evening
- The efficacy of taking amlodipine in the morning and lisinopril in the evening can be evaluated based on the available studies.
- A study published in 1998 2 found that both morning and evening administrations of amlodipine significantly reduced elevated systolic and diastolic blood pressures during daytime.
- Another study published in 2019 3 found that administration of amlodipine in the evening could significantly reduce nighttime blood pressure and had better anti-hypertension efficacy.
Combination Therapy with Amlodipine and Lisinopril
- A study published in 1996 4 found that the combination of amlodipine and lisinopril had a synergistic effect in patients with more severe hypertension.
- The same study found that adding a diuretic to the combination of amlodipine and lisinopril was more effective than adding a beta-blocker in reducing blood pressure.
- A study published in 2020 5 recommended that patients with hypertension should be treated with combination therapy, including a calcium channel blocker, an angiotensin-converting enzyme inhibitor, and a thiazide diuretic.
Timing of Amlodipine Administration
- The study published in 2019 3 found that taking amlodipine in the evening was more beneficial for patients with non-dipper hypertension.
- The study published in 1998 2 found that the early morning rise in blood pressure was decreased after morning dosing of amlodipine, which may be advantageous in reducing early morning cardiovascular risk.
Overall Efficacy
- The available studies suggest that taking amlodipine in the morning and lisinopril in the evening may be an effective combination therapy for reducing blood pressure.
- However, the optimal timing of amlodipine administration may depend on the individual patient's blood pressure profile and other factors, such as the presence of non-dipper hypertension 3.