What is the diagnosis and treatment for a subdermal (under the skin) cyst?

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Last updated: May 19, 2025View editorial policy

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From the Guidelines

For a subdermal cyst, incision and drainage is the recommended treatment if it becomes inflamed, as this approach is strongly supported by high-quality evidence. This method is effective in treating inflamed epidermoid cysts, which are a type of subdermal cyst, as stated in the 2014 update by the Infectious Diseases Society of America 1. According to this guideline, incision and drainage is the recommended treatment for inflamed epidermoid cysts.

When considering the management of subdermal cysts, it's essential to differentiate between inflamed and uninflamed cysts. For uninflamed cysts, treatment may not be necessary unless they become symptomatic or cosmetically bothersome. However, if a cyst becomes infected, as indicated by signs of inflammation, redness, or drainage, medical attention is required. In such cases, antibiotics may be prescribed, but the decision to administer them should be based on the presence of systemic inflammatory response syndrome (SIRS), as recommended by the guidelines 1.

Key points to consider in the management of subdermal cysts include:

  • Avoiding self-drainage or squeezing the cyst to prevent infection or scarring
  • Applying warm compresses to reduce inflammation if the cyst becomes tender
  • Seeking medical attention if the cyst becomes red, painful, or starts draining, as these signs may indicate infection
  • Considering surgical excision for symptomatic cysts to prevent recurrence

It's also important to note that subdermal cysts, including epidermoid cysts, typically contain skin flora, and their inflammation is often a reaction to the rupture of the cyst wall rather than an infectious complication, as discussed in the 2005 practice guidelines for the diagnosis and management of skin and soft-tissue infections 1. However, the most recent and highest quality evidence from 2014 should guide clinical decision-making 1.

From the Research

Subdermal Cyst Treatment Options

  • Percutaneous sclerotherapy is a treatment option for cystic lesions, including subdermal cysts, as described in 2.
  • Aspiration and sclerotherapy can be effective in managing symptomatic cysts, but may not provide long-term control in all cases, as seen in 3.

Sclerotherapy Agents and Techniques

  • A 95% alcohol solution can be used as a sclerosing agent for hepatic cysts, as described in 4.
  • Tetracycline solution can be used for renal cysts, providing both sclerosing action and antibiotic prophylaxis, as described in 5.

Efficacy and Safety of Aspiration-Sclerotherapy

  • Aspiration-sclerotherapy can be an effective first-line therapy for symptomatic simple renal cysts, with a high treatment success rate and low complication rate, as reported in 6.
  • The use of a sclerosing agent is integral to treatment success, but the optimum agent, volume, injection frequency, and dwelling time are yet to be defined, as noted in 6.

Considerations for Treatment

  • Cyst size should be considered when discussing treatment options, but aspiration-sclerotherapy can be used in the first instance for all cases of symptomatic simple renal cysts, as proposed in 6.
  • Prior manipulation of the cyst does not adversely affect subsequent surgical procedures, as seen in 3.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Percutaneous sclerotherapy of cystic lesions.

Seminars in interventional radiology, 2012

Research

Splenic cysts: aspiration, sclerosis, or resection.

Journal of pediatric surgery, 1989

Research

Percutaneous treatment of hepatic cysts by aspiration and sclerotherapy.

Cardiovascular and interventional radiology, 1993

Research

Antibiotic sclerotherapy for renal cysts.

RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 1989

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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