What causes mid-right abdominal tenderness on deep palpation?

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Last updated: May 20, 2025View editorial policy

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Differential Diagnosis for Mid Right Abdominal Pain on Deep Palpation

The following differential diagnosis is organized into categories to help guide the thought process:

  • Single Most Likely Diagnosis
    • Appendicitis: This is the most likely diagnosis due to the location of the pain (mid right abdomen) and the exacerbation of pain on deep palpation, which is a classic sign of appendicitis.
  • Other Likely Diagnoses
    • Cholecystitis: Inflammation of the gallbladder can cause right upper quadrant pain that may radiate to the mid right abdomen and worsen with deep palpation.
    • Peptic Ulcer Disease: A peptic ulcer in the duodenum can cause mid right abdominal pain, especially if it is located near the pylorus.
    • Intestinal Obstruction: A partial or complete obstruction of the small intestine can cause abdominal pain, including in the mid right region, and may worsen with deep palpation.
    • Inflammatory Bowel Disease (IBD): Conditions like Crohn's disease or ulcerative colitis can cause chronic abdominal pain, including in the mid right region, and may worsen with deep palpation.
  • Do Not Miss Diagnoses
    • Ectopic Pregnancy: Although less likely, an ectopic pregnancy can cause abdominal pain, including in the mid right region, and is a life-threatening condition if missed.
    • Ruptured Aortic Aneurysm: A ruptured abdominal aortic aneurysm can cause severe abdominal pain, including in the mid right region, and is a medical emergency.
    • Ovarian Torsion: Torsion of the ovary can cause severe abdominal pain, including in the mid right region, and is a surgical emergency.
  • Rare Diagnoses
    • Mesenteric Lymphadenitis: Inflammation of the lymph nodes in the mesentery can cause abdominal pain, including in the mid right region.
    • Right Lower Lobe Pneumonia: A pneumonia in the right lower lobe can cause referred pain to the mid right abdomen.
    • Pancreatitis: Although pancreatitis typically causes upper abdominal pain, it can occasionally cause mid right abdominal pain, especially if the pancreatic tail is involved.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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