From the FDA Drug Label
Misuse and abuse of lisdexamfetamine, a prodrug of amphetamine, may cause increased heart rate, respiratory rate, or blood pressure; sweating; dilated pupils; hyperactivity; restlessness; insomnia; decreased appetite; loss of coordination; tremors; flushed skin; vomiting; and/or abdominal pain Anxiety, psychosis, hostility, aggression, and suicidal or homicidal ideation have also been observed with CNS stimulants abuse and/or misuse.
The potential complications for a 24-year-old female who took Vyvanse (lisdexamfetamine) and consumed alcohol, now presenting with vomiting, may include:
- Increased heart rate, respiratory rate, or blood pressure
- Sweating
- Dilated pupils
- Hyperactivity
- Restlessness
- Insomnia
- Decreased appetite
- Loss of coordination
- Tremors
- Flushed skin
- Abdominal pain
- Anxiety
- Psychosis
- Hostility
- Aggression
- Suicidal or homicidal ideation 1 1
From the Research
Seek immediate medical attention, as the combination of Vyvanse and alcohol can be dangerous and potentially life-threatening. The patient's vomiting could be a sign of alcohol poisoning or a severe drug interaction, and the mixture of Vyvanse and alcohol can increase the risk of cardiovascular problems, dehydration, and impaired judgment 2.
While waiting for medical help:
- Stay with the person and keep them awake
- Have them sit upright to prevent choking if vomiting continues
- Provide water if they can keep it down to prevent dehydration Do not induce vomiting or give any other medications, as medical professionals need to assess and treat this situation, which may require intravenous fluids, monitoring of vital signs, and possibly other interventions 3, 4.
It is essential to note that the patient may be at risk for complications such as Boerhaave syndrome, a spontaneous esophageal rupture caused by forceful vomiting, which can be fatal if not treated promptly 5. Additionally, the patient should be advised to avoid alcohol consumption while taking Vyvanse or other stimulants, as this can lead to increased risk of toxicity and adverse reactions 6.
In the future, it is crucial to never mix Vyvanse or other stimulants with alcohol, as these substances have opposing effects on the body and can mask each other's symptoms, leading to overconsumption and increased risk of toxicity 2. Medical professionals should educate patients about the potential dangers of combining these substances and the importance of seeking medical attention immediately if they experience any adverse effects.