What is the diagnosis for a patient with low lipase levels, mild hematuria (presence of red blood cells in urine), mild leukocyturia (presence of white blood cells in urine), and impaired renal function (elevated creatinine and decreased eGFR), with a normal complete blood count (CBC) and negative chest and abdomen X-rays?

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Differential Diagnosis

The patient's presentation is complex, with abnormal urinalysis and CBC results, as well as an elevated creatinine level. Here are the potential diagnoses, categorized for clarity:

  • Single Most Likely Diagnosis
    • Urinary Tract Infection (UTI): The presence of WBCs, RBCs, bacteria, and leukocyte esterase in the urinalysis suggests a UTI. The patient's symptoms and lab results are consistent with this diagnosis.
  • Other Likely Diagnoses
    • Chronic Kidney Disease (CKD): The elevated creatinine level and decreased eGFR indicate impaired kidney function, which may be due to CKD.
    • Dehydration: The patient's lab results do not show significant electrolyte imbalances, but dehydration could contribute to the elevated creatinine level.
    • Pyelonephritis: The presence of WBCs and RBCs in the urinalysis, along with the patient's symptoms, could suggest pyelonephritis, an infection of the kidney.
  • Do Not Miss Diagnoses
    • Sepsis: Although the patient's CBC results do not show significant abnormalities, the presence of bacteria in the urinalysis and the elevated creatinine level could indicate a systemic infection.
    • Kidney Stones: The patient's symptoms and lab results could be consistent with kidney stones, which would require prompt medical attention.
    • Glomerulonephritis: The presence of RBCs and WBCs in the urinalysis could suggest an inflammatory process, such as glomerulonephritis.
  • Rare Diagnoses
    • Interstitial Nephritis: The patient's symptoms and lab results could be consistent with interstitial nephritis, an inflammatory process affecting the kidney tissue.
    • Vasculitis: The presence of RBCs and WBCs in the urinalysis, along with the patient's symptoms, could suggest a vasculitic process affecting the kidneys.
    • Malignancy: Although unlikely, the patient's symptoms and lab results could be consistent with a malignancy, such as bladder or kidney cancer.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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