From the Guidelines
Morganella morganii urinary tract infections should be treated with a combination of antibiotics, such as amoxicillin plus an aminoglycoside or a second-generation cephalosporin plus an aminoglycoside, as recommended by the European Association of Urology guidelines 1. When considering treatment options, it's essential to prioritize the patient's morbidity, mortality, and quality of life. The European Association of Urology guidelines provide strong recommendations for the treatment of complicated UTIs, including the use of combination therapy 1.
- The guidelines recommend using a combination of antibiotics, such as amoxicillin plus an aminoglycoside or a second-generation cephalosporin plus an aminoglycoside, for the treatment of complicated UTIs 1.
- Additionally, the guidelines suggest that ciprofloxacin can be used only if the local resistance rate is <10% and the patient does not require hospitalization 1.
- It's also important to manage any urological abnormality and/or underlying complicating factors to ensure successful treatment 1.
- A study published in 2023 found that short-duration therapy (5-7 days) can be effective for complicated UTIs, including those caused by Morganella morganii, but more data are needed to confirm this finding, especially in men 1.
- However, the most recent and highest-quality study, published in 2024, recommends using combination therapy for complicated UTIs, which takes priority over the 2023 study 1.
- Therefore, the recommended treatment for Morganella morganii urinary tract infections is a combination of antibiotics, such as amoxicillin plus an aminoglycoside or a second-generation cephalosporin plus an aminoglycoside, as recommended by the European Association of Urology guidelines 1.
From the FDA Drug Label
URINARY TRACT INFECTIONS (complicated and uncomplicated) Caused by Escherichia coli, Proteus mirabilis, Proteus vulgaris, Morganella morganii or Klebsiella pneumoniae Urinary Tract Infections For the treatment of urinary tract infections due to susceptible strains of the following organisms: Escherichia coli, Klebsiella species, Enterobacter species, Morganella morganii, Proteus mirabilis and Proteus vulgaris
- Treatment options for Morganella morganii in urine include:
- Key points:
- Both ceftriaxone and trimethoprim-sulfamethoxazole are indicated for the treatment of urinary tract infections caused by Morganella morganii.
- The choice of treatment should be based on susceptibility testing and local epidemiology.
From the Research
Morganella morganii in Urine Treatment
- Morganella morganii is a Gram-negative, opportunistic pathogen that can cause various infections, including urinary tract infections (UTIs) 4, 5.
- The treatment of M. morganii infections, including UTIs, often involves the use of antibiotics such as carbapenems, aminoglycosides, and third-generation cephalosporins 4, 6.
- However, M. morganii is often resistant to multiple antibiotics, including ciprofloxacin, trimethoprim/sulfamethoxazole, gentamicin, amoxicillin, nitrofurantoin, and colistin 4.
- The natural antibiotic susceptibility of M. morganii has been studied, and it has been found to be naturally resistant to certain penicillins, cephalosporins, and other antibiotics, but sensitive to aminoglycosides, piperacillin, and carbapenems 7.
- The use of gentamicin in combination with a third-generation cephalosporin or another antibiotic to which M. morganii is susceptible has been recommended for the treatment of M. morganii infections 6.
- Source control measures, such as surgery, line removal, drainage, and tissue removal, may also be necessary in some cases to improve outcomes 4.
- The prevalence of virulence factors and antimicrobial resistance in M. morganii isolates from UTIs has been studied, and it has been found that hospital strains often show a higher prevalence of virulence genes and resistance to antibiotics compared to community strains 5.