From the Research
No, Morganella morganii is typically not sensitive to Flagyl (metronidazole). Metronidazole is primarily effective against anaerobic bacteria and certain parasites, while Morganella is a gram-negative, facultative anaerobic bacterium that belongs to the Enterobacteriaceae family.
Key Points to Consider
- Morganella infections are usually treated with antibiotics that are effective against gram-negative bacteria, such as third-generation cephalosporins, fluoroquinolones, aminoglycosides, or carbapenems, depending on susceptibility testing 1.
- It's essential to note that Morganella species frequently develop resistance to multiple antibiotics, including ampicillin and first-generation cephalosporins due to chromosomally encoded beta-lactamases 2.
- When treating a Morganella infection, antibiotic susceptibility testing should be performed to guide appropriate therapy, as resistance patterns can vary between isolates and geographic regions 3.
- A recent study found that Morganella morganii is often resistant to multiple antibiotics, including ciprofloxacin, trimethoprim/sulfamethoxazole, gentamicin, amoxicillin, nitrofurantoin, and colistin 4.
- The most common treatment for M. morganii bacteremia was carbapenems, followed by aminoglycosides, ciprofloxacin, and colistin 4.
Recommendations
- Antibiotic susceptibility testing should be performed to guide appropriate therapy for Morganella infections, as resistance patterns can vary between isolates and geographic regions 1.
- Treatment of Morganella infections should include antibiotics that are effective against gram-negative bacteria, such as third-generation cephalosporins, fluoroquinolones, aminoglycosides, or carbapenems, depending on susceptibility testing 3.
- It's crucial to monitor for resistance and adjust treatment accordingly, as Morganella species can develop resistance to multiple antibiotics 2.