From the Research
Yes, meloxicam can potentially cause oral ulcers as a side effect, though it's not one of the most common adverse reactions. Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation. While oral ulcers are not among the most frequently reported side effects, they can occur in some individuals taking this medication, as it may cause gastrointestinal adverse events, including ulceration and bleeding 1. If you develop oral ulcers while taking meloxicam, consult your healthcare provider. They may recommend:
- Continuing the medication if the ulcers are mild and tolerable
- Reducing the dose (typically from 15 mg to 7.5 mg daily)
- Switching to a different NSAID or pain management strategy To minimize the risk of oral ulcers and other gastrointestinal side effects:
- Take meloxicam with food or milk
- Use the lowest effective dose for the shortest duration necessary
- Stay well-hydrated The mechanism behind NSAID-induced oral ulcers is related to their inhibition of prostaglandin synthesis, which can reduce the protective factors in the oral mucosa, making the tissue more susceptible to irritation and ulceration 2. It's worth noting that meloxicam has been shown to cause fewer adverse gastrointestinal events compared to non-COX-2-selective NSAIDs, with a lower rate of dyspepsia, perforations, ulcers, and bleeds (PUBs) 2. However, the risk of gastrointestinal side effects, including oral ulcers, should still be considered when prescribing meloxicam, especially in patients with a history of gastrointestinal disorders 3.