What is the diagnosis for a 30-year-old male with a persistent, eraser-sized (approximately 2.5 cm) nodule on his neck for several months?

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Differential Diagnosis for a 30-year-old Male with an Eraser-Sized Bump on the Neck

  • Single most likely diagnosis
    • Lipoma: A benign tumor composed of fat tissue, which is common in adults and can present as a soft, movable lump under the skin, consistent with the description of an eraser-sized bump.
  • Other Likely diagnoses
    • Cyst (e.g., sebaceous or epidermoid): These are benign, fluid-filled sacs that can form under the skin and may appear as a lump, similar to the one described.
    • Lymphadenopathy (reactive or infectious): Enlarged lymph nodes can present as bumps on the neck, often due to the body's response to infection or inflammation.
    • Dermatofibroma: A benign skin growth that can appear as a firm, round bump, often resulting from minor injury, which might fit the description given.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed)
    • Metastatic cancer (e.g., from thyroid, lung, or other primary sites): Although less common, a lump on the neck can be a sign of metastasis from a primary cancer, which would have significant implications for treatment and prognosis.
    • Lymphoma: Both Hodgkin and non-Hodgkin lymphoma can present with lymphadenopathy, which might initially appear as a lump on the neck.
    • Thyroid nodule or cancer: Abnormal growths on the thyroid gland can sometimes be felt as lumps on the neck and require urgent evaluation due to the potential for malignancy.
  • Rare diagnoses
    • Branchial cleft cyst: A congenital anomaly that can present as a lump along the side of the neck, often becoming apparent in young adulthood.
    • Carotid body tumor: A rare, usually benign tumor located at the bifurcation of the carotid artery, which can present as a neck mass.
    • Neurofibroma: A benign tumor of the nerve tissue, which can occur anywhere, including the neck, and is more common in individuals with neurofibromatosis type 1.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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