From the Guidelines
Tebonin, a Ginkgo biloba extract supplement, is generally considered to have mild side effects, including headache, dizziness, and digestive issues, but its use should be approached with caution due to potential interactions with other medications and bodily processes, as noted in studies on similar supplements 1.
Common Side Effects
- Headache
- Dizziness
- Digestive issues like nausea or diarrhea
- Allergic skin reactions
Serious but Rare Side Effects
- Increased bleeding risk, especially for those on blood thinners like warfarin or aspirin, which is a concern due to the effects of Ginkgo biloba on blood circulation, as discussed in the context of patients with peripheral arterial disease 1
- Heart palpitations or changes in blood pressure
Special Considerations
- Individuals with bleeding disorders, scheduled for surgery, pregnant, breastfeeding, or taking medications should consult a healthcare provider before using Tebonin, given the potential for interactions and the lack of comprehensive data on its safety in these populations 1
- The standard dose is typically 120-240 mg daily, divided into 2-3 doses, but this may need to be adjusted based on individual response and medical history
- If persistent or severe side effects occur, it is recommended to stop taking Tebonin and consult a healthcare provider, prioritizing caution and monitoring for any adverse effects 1
From the Research
Tebonin Side Effects
Tebonin, a standardized extract of Ginkgo biloba leaves, has been studied for its potential side effects. The evidence suggests that:
- Ginkgo biloba extract, including Tebonin, may cause minor side effects such as stomach upset, headache, dizziness, constipation, forceful heartbeat, and allergic skin reactions 2
- There is some concern that Ginkgo biloba leaf extract might increase the risk of bruising and bleeding, and interactions with anticoagulants/antiplatelet drugs cannot be ruled out 2, 3
- The combination of Ginkgo biloba with antiplatelet or anticoagulant drugs may represent a risk of hemorrhage, particularly in patients aged 65 and older, and male patients 4
- Ginkgo biloba extract appears to be safe to use, with no excess side effects compared with placebo, but caution is advised when recommending it to patients taking anticoagulants 2, 5
Potential Interactions
Some studies have investigated the potential interaction of Ginkgo biloba leaf with antiplatelet or anticoagulant drugs, and the evidence suggests that:
- Controlled studies consistently indicate that Ginkgo does not significantly impact haemostasis nor adversely affect the safety of coadministered aspirin or warfarin 3
- The possibility of an idiosyncratic bleeding event due to Ginkgo use cannot be excluded on the basis of the available information 3
- There is scant information from case reports or controlled trials to support the suggestion that Ginkgo potentiates the effects of anticoagulant or antiplatelet drugs 3
Precautions
As a general precaution, it is recommended to: