From the Guidelines
Butrans (buprenorphine transdermal patch) can cause indigestion and nausea as side effects, with nausea affecting approximately 10-25% of patients who use it, as supported by various studies 1. The most recent and highest quality study, although not directly addressing Butrans, provides insight into opioid-induced nausea and vomiting, suggesting that these side effects are common among opioid users 1. Some key points to consider regarding nausea and vomiting in patients using opioids like Butrans include:
- Nausea is a common side effect, especially when first starting the medication or increasing the dose.
- Indigestion or stomach discomfort may also occur due to the opioid's effect on the digestive tract and the brain's chemoreceptor trigger zone.
- If experiencing these side effects, it's crucial not to suddenly stop using Butrans, as this could lead to withdrawal symptoms.
- Consulting with a healthcare provider is recommended, as they might suggest anti-nausea medications, taking the medication with food, or adjusting the dosage if symptoms are severe or persistent.
- Other studies highlight the importance of managing opioid-induced adverse effects, including nausea, through various strategies such as prophylactic antiemetic treatment, opioid rotation, and the use of alternative agents like serotonin receptor antagonists or corticosteroids 1. Given the potential for nausea and indigestion, it is essential for patients using Butrans to be aware of these possible side effects and to discuss any concerns with their healthcare provider to manage them effectively and minimize their impact on quality of life.
From the Research
Buprenorphine and Gastrointestinal Side Effects
- Buprenorphine, the active ingredient in Butrans, has been associated with gastrointestinal side effects such as nausea and vomiting 2.
- A study published in 1991 found that buprenorphine caused substantially more nausea and vomiting than other compounds, and this effect was more intense when participants were ambulating 2.
- The exact mechanism of this effect is not fully understood, but high-affinity receptor binding may play a role in the long duration of nausea and vomiting after a single dose of buprenorphine 2.
Butrans and Indigestion or Nausea
- While there is no direct evidence on Butrans specifically, the studies on buprenorphine suggest that it may cause indigestion or nausea as a side effect 2.
- However, a review of buprenorphine treatment for opioid use disorder published in 2019 does not mention indigestion or nausea as a common side effect, but it does discuss the efficacy and challenges of buprenorphine treatment 3.
- It is essential to note that the formulation and administration of buprenorphine in Butrans may affect the incidence and severity of gastrointestinal side effects, but more research is needed to fully understand this relationship.