What are the contraindications for Femene (Estradiol) plus?

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Last updated: May 21, 2025View editorial policy

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From the Guidelines

Femenista Plus is contraindicated in women with a history of breast cancer, liver disease, myocardial infarction, known or suspected estrogen-dependent neoplasia, deep vein thrombosis, or thrombophilic disorders. These conditions increase the risk of adverse effects from the hormonal components of Femenista Plus. According to the 2024 guideline for the primary prevention of stroke by the American Heart Association/American Stroke Association 1, assessing for contraindications to menopausal hormone therapy use is crucial. The guideline lists specific contraindications, including history of breast cancer, liver disease, history of myocardial infarction, known or suspected estrogen-dependent neoplasia, history of deep vein thrombosis, and thrombophilic disorders.

Some key points to consider when evaluating the use of Femenista Plus include:

  • History of breast cancer or other estrogen-dependent neoplasms
  • Active or recent arterial thromboembolic disease, such as stroke or myocardial infarction
  • Active venous thromboembolism or a history of these conditions
  • Severe liver disease
  • Undiagnosed abnormal vaginal bleeding
  • Known or suspected pregnancy
  • Hypersensitivity to any components of the product

It is essential to consult with a healthcare provider before starting Femenista Plus to ensure it is appropriate for the individual's specific health situation, considering the potential risks and benefits. The healthcare provider should assess for contraindications and discuss alternative treatment options if necessary.

The evidence from the 2024 guideline 1 provides the most recent and highest quality information on the contraindications for menopausal hormone therapy, including Femenista Plus. While other studies, such as those from 2017 1, 2013 1, 2012 1, and 2012 1, provide additional information on the risks and benefits of hormone therapy, the 2024 guideline offers the most up-to-date and relevant guidance on contraindications.

From the Research

Femenista Plus Contraindication

  • There are no research papers to assist in answering this question regarding "femenista plus contraindication" as the provided studies focus on thromboembolism in pregnancy, its diagnosis, treatment, and prevention.
  • However, the studies do mention contraindications for certain medications during pregnancy, such as:
    • Warfarin should be avoided in the antepartum period due to teratogenicity 2
    • Non-vitamin K oral anticoagulants are currently not recommended due to the lack of data 2
    • Direct oral anticoagulants are contraindicated during pregnancy and in breastfeeding women 3
  • These studies provide information on the management of thromboembolism in pregnancy, including the use of low-molecular-weight heparin for prophylaxis and treatment 2, 3.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Pulmonary Embolism in Pregnancy.

Seminars in respiratory and critical care medicine, 2021

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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