From the Guidelines
Mixing Vyvanse (lisdexamfetamine) with alcohol is not recommended under any circumstances. These substances have opposing effects on the body—Vyvanse is a stimulant while alcohol is a depressant—creating unpredictable and potentially dangerous interactions. When combined, alcohol can mask Vyvanse's stimulant effects, potentially leading to excessive drinking and alcohol poisoning. Additionally, this combination increases strain on the cardiovascular system, raising the risk of irregular heartbeat, elevated blood pressure, and heart problems. Vyvanse can also reduce your perception of alcohol intoxication, causing you to drink more than intended. Both substances affect the liver, and combining them increases the risk of liver damage.
Key Considerations
- The study by Scoten 1 focuses on the use of psychostimulants, including lisdexamfetamine (Vyvanse), in pregnancy and the postpartum period, highlighting the importance of cautious use due to limited published information on its effects during these periods.
- While the provided study 1 does not directly address the interaction between Vyvanse and alcohol, the principles of pharmacology and the known effects of stimulants and depressants suggest a potentially hazardous combination.
- If you're prescribed Vyvanse for ADHD or binge eating disorder, it's crucial to speak with your healthcare provider about alcohol use, as they can provide personalized advice and support.
Recommendations
- Never adjust your medication schedule to accommodate drinking.
- If you struggle with limiting alcohol consumption, discuss this with your doctor, who can offer appropriate support and resources.
- Be aware of the potential for increased strain on the cardiovascular system and the risk of liver damage when combining these substances.
- Always prioritize open communication with your healthcare provider regarding your medication and alcohol use to ensure the best possible outcomes for your health.
From the Research
Vyvanse and Alcohol Interaction
- There are no direct studies on the interaction between Vyvanse (lisdexamfetamine) and alcohol in the provided evidence.
- However, it is known that Vyvanse is a central nervous system stimulant, and consuming alcohol while taking Vyvanse may increase the risk of adverse effects such as increased heart rate, blood pressure, and anxiety 2, 3.
- A study on the treatment of methamphetamine withdrawal using lisdexamfetamine found that participants received standard inpatient withdrawal care, which may include management of alcohol withdrawal symptoms, but it does not specifically address the interaction between Vyvanse and alcohol 4.
- Another study on the use of lisdexamfetamine for cocaine use disorder found that participants were able to achieve a mean dose of 118.1 mg of lisdexamfetamine, but it does not mention the interaction with alcohol 5.
- A pharmacokinetic review of lisdexamfetamine found that its pharmacokinetics are relatively predictable, but it does not discuss the interaction with alcohol 6.
Potential Risks
- Combining Vyvanse with alcohol may increase the risk of adverse effects, but the exact nature of this interaction is not well-studied in the provided evidence.
- Patients taking Vyvanse should be cautious when consuming alcohol, as it may exacerbate existing health conditions or interact with other medications 2, 3.
- Further research is needed to fully understand the potential risks and interactions between Vyvanse and alcohol.