Differential Diagnosis for Urethral Discharge with Negative STD
Single Most Likely Diagnosis
- Urethral stricture or urethral trauma: This is a common cause of urethral discharge in the absence of a sexually transmitted disease (STD), as it can lead to chronic inflammation and infection.
Other Likely Diagnoses
- Prostatitis: Inflammation of the prostate gland can cause urethral discharge, and it is a common condition in men.
- Urethritis due to non-sexually transmitted organisms: Bacteria such as E. coli, Klebsiella, or Pseudomonas can cause urethritis, leading to discharge.
- Foreign body in the urethra: The presence of a foreign object in the urethra can cause irritation, inflammation, and discharge.
Do Not Miss Diagnoses
- Tuberculosis (TB) of the genitourinary tract: Although rare, TB can cause urethral discharge and is a critical diagnosis to consider due to its potential for severe consequences if left untreated.
- Malignancy of the urethra or prostate: Cancer of the urethra or prostate can cause urethral discharge, and early detection is crucial for effective treatment.
- Urinary tract infection (UTI) with an obstructing lesion: A UTI with an underlying obstructing lesion, such as a kidney stone or tumor, can cause urethral discharge and requires prompt attention to prevent complications.
Rare Diagnoses
- Reiter's syndrome: A rare condition characterized by a combination of urethritis, conjunctivitis, and arthritis, which can cause urethral discharge.
- Urethral diverticulum: A congenital or acquired condition where a pouch forms in the urethral wall, which can become infected and cause discharge.
- Sjögren's syndrome: An autoimmune disorder that can cause inflammation and dryness in various parts of the body, including the urethra, leading to discharge.