From the FDA Drug Label
16 HOW SUPPLIED/STORAGE AND HANDLING
Store unreconstituted powder at 20°C to 25° C (68°F to 77° F) [See USP Controlled Room Temperature]
The FDA drug label does not answer the question.
From the Research
Amoxicillin is typically effective for one year from the date of dispensing when stored properly, after which it should be discarded to ensure potency and safety. The effectiveness of amoxicillin is influenced by its storage conditions, with proper storage meaning it should be kept in its original container at room temperature (between 68-77°F or 20-25°C), away from excessive heat, moisture, and direct light 1. For liquid amoxicillin suspensions, once reconstituted with water, they are generally good for only 14 days when refrigerated. It's crucial to note that using expired antibiotics can be dangerous as they may be less effective at treating infections, potentially leading to antibiotic resistance or treatment failure. The chemical structure of amoxicillin gradually breaks down over time, which reduces its ability to kill bacteria effectively.
Some studies have compared the efficacy of amoxicillin with other antibiotics, such as cefaclor and azithromycin, in treating various infections, including acute otitis media and pharyngotonsillitis 2, 3, 4, 5. However, these studies do not directly address the shelf life of amoxicillin.
In clinical practice, it is essential to prioritize the safe and effective use of antibiotics, including proper storage and disposal of unused or expired medications. If you have leftover or expired amoxicillin, it is recommended to dispose of it properly through medication take-back programs or by mixing it with unpalatable substances before throwing it in the trash.
Key points to consider:
- Amoxicillin is generally effective for one year from the date of dispensing when stored properly.
- Proper storage conditions are crucial to maintain the potency and safety of amoxicillin.
- Using expired antibiotics can be dangerous and may lead to antibiotic resistance or treatment failure.
- Liquid amoxicillin suspensions have a shorter shelf life once reconstituted with water.
- Proper disposal of unused or expired amoxicillin is essential to prevent misuse and environmental contamination.