What is the use of Serrapeptase (Serratia peptidase) in pediatric patients?

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Last updated: May 22, 2025View editorial policy

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From the Guidelines

Serrapeptase is not recommended for children due to insufficient research on its safety and effectiveness in pediatric populations. The lack of FDA approval for use in children and the absence of established dosing guidelines are significant concerns 1. Potential side effects of serrapeptase in children could include digestive upset, allergic reactions, or bleeding risks.

Alternative Treatments

For children with inflammation, pain, or swelling, it is better to consult with a pediatrician who can recommend age-appropriate, evidence-based treatments. Conventional treatments such as acetaminophen or ibuprofen (for children over 6 months) have well-documented dosing guidelines and safety information specifically for pediatric use 1. These medications are more reliable choices for managing childhood inflammatory conditions.

Key Considerations

  • Insufficient research on serrapeptase in pediatric populations
  • Lack of FDA approval for use in children
  • No established dosing guidelines for children
  • Potential side effects, including digestive upset, allergic reactions, or bleeding risks
  • Alternative treatments, such as acetaminophen or ibuprofen, have established safety profiles in children 1

Recommendation

Consult with a pediatrician to determine the best course of treatment for a child's inflammatory condition, rather than using serrapeptase 1. This ensures that the child receives an evidence-based treatment with a well-established safety profile.

From the Research

Serratiopeptidase for Children

There is limited information available on the use of serratiopeptidase in children.

  • The existing studies on serratiopeptidase primarily focus on its anti-inflammatory, anti-edemic, and analgesic effects in various clinical specialties, including surgery, orthopedics, and otorhinolaryngology 2.
  • Some studies suggest that serratiopeptidase may have potential therapeutic applications due to its proteolytic properties, including anti-inflammatory and anti-biofilm activities 3, 4.
  • However, there are also reports of serratiopeptidase potentially causing the spread of infection due to its fibrinolytic activity, highlighting the need for cautious use 5.
  • A review of the therapeutic applications of serratiopeptidase emphasizes the need for more scientific data to support its efficacy and safety, particularly in pediatric populations 6.

Key Considerations

  • The lack of studies specifically focusing on the use of serratiopeptidase in children makes it challenging to determine its safety and efficacy in this population.
  • The available evidence on serratiopeptidase is primarily based on adult studies, and its application in children would require careful consideration of potential risks and benefits.
  • Further research is needed to explore the potential therapeutic applications of serratiopeptidase in children and to establish clear guidelines for its use in pediatric populations.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Serratiopeptidase: a systematic review of the existing evidence.

International journal of surgery (London, England), 2013

Research

The role of serratiopeptidase in the resolution of inflammation.

Asian journal of pharmaceutical sciences, 2017

Research

Serratiopeptidase - A Cause for Spread of Infection.

Journal of clinical and diagnostic research : JCDR, 2016

Research

Serratiopeptidase: Insights into the therapeutic applications.

Biotechnology reports (Amsterdam, Netherlands), 2020

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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